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Chronic Exposure to the Herbicide, Atrazine, Causes Mitochondrial Dysfunction and Insulin Resistance
DC Field | Value | Language |
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dc.contributor.author | Lim, Soo | - |
dc.contributor.author | Ahn, Sun Young | - |
dc.contributor.author | Song, In Chan | - |
dc.contributor.author | Chung, Myung Hee | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Pak, Youngmi Kim | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Lee, Ki-Up | - |
dc.contributor.author | Jang, Hak Chul | - |
dc.date.accessioned | 2012-06-22T07:43:17Z | - |
dc.date.available | 2012-06-22T07:43:17Z | - |
dc.date.issued | 2009-04-13 | - |
dc.identifier.citation | PLOS ONE; Vol.4 4; e5186 | ko_KR |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77334 | - |
dc.description.abstract | There is an apparent overlap between areas in the USA where the herbicide, atrazine (ATZ), is heavily used and obesity-prevalence maps of people with a BMI over 30. Given that herbicides act on photosystem II of the thylakoid membrane of chloroplasts, which have a functional structure similar to mitochondria, we investigated whether chronic exposure to low concentrations of ATZ might cause obesity or insulin resistance by damaging mitochondrial function. Sprague-Dawley rats (n = 48) were treated for 5 months with low concentrations (30 or 300 mu g kg(-1) day(-1)) of ATZ provided in drinking water. One group of animals was fed a regular diet for the entire period, and another group of animals was fed a high-fat diet (40% fat) for 2 months after 3 months of regular diet. Various parameters of insulin resistance were measured. Morphology and functional activities of mitochondria were evaluated in tissues of ATZ-exposed animals and in isolated mitochondria. Chronic administration of ATZ decreased basal metabolic rate, and increased body weight, intra-abdominal fat and insulin resistance without changing food intake or physical activity level. A high-fat diet further exacerbated insulin resistance and obesity. Mitochondria in skeletal muscle and liver of ATZ-treated rats were swollen with disrupted cristae. ATZ blocked the activities of oxidative phosphorylation complexes I and III, resulting in decreased oxygen consumption. It also suppressed the insulin-mediated phosphorylation of Akt. These results suggest that long-term exposure to the herbicide ATZ might contribute to the development of insulin resistance and obesity, particularly where a high-fat diet is prevalent. | ko_KR |
dc.description.sponsorship | This work is supported by the IT R&D program of MIC/IITA [2006-S075-01 to HK Lee, Development of an early diagnostic system of metabolic syndrome
based on nanosensor integrated network computing], a Korea Science and Engineering Foundation (KOSEF) grant (M10642140004-06N4214-00410 to YK Pak) and a grant from the 21C Frontier Functional Proteomics Project (FPR08A1-070 to YK Pak) from the Ministry of Education, Science & Technology, Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PUBLIC LIBRARY SCIENCE | ko_KR |
dc.title | Chronic Exposure to the Herbicide, Atrazine, Causes Mitochondrial Dysfunction and Insulin Resistance | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 임수 | - |
dc.contributor.AlternativeAuthor | 안선영 | - |
dc.contributor.AlternativeAuthor | 송인찬 | - |
dc.contributor.AlternativeAuthor | 정명희 | - |
dc.contributor.AlternativeAuthor | 장학철 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 이기업 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.identifier.doi | 10.1371/journal.pone.0005186 | - |
dc.citation.journaltitle | PLOS ONE | - |
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dc.description.tc | 16 | - |
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