Browse

Detection of Differential Proteomes of Human beta-Cells During Islet-Like Differentiation Using iTRAQ Labeling

Cited 24 time in Web of Science Cited 28 time in Scopus
Authors
Jin, Jonghwa; Park, Jungeun; Kim, Kyunggon; Kang, Yup; Kim, Jae Hyeon; Jun, Heesook; Kim, Youngsoo; Park, Kyong Soo; Park, Sang Gyu
Issue Date
2009-03
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF PROTEOME RESEARCH; Vol.8 3; 1393-1403
Keywords
human beta-cell lineRNAKT-15 celliTRAQislet transplantationbeta-cell differentiation
Abstract
A human beta-cell line, RNAKT-15, was recently established from human pancreatic islets, whereby its differentiation into islet-like beta-cells (islet-like RNAKT-15) increased its expression of insulin 2-fold compared with RNAKT-15 cells. To characterize the differentiation of RNAKT-15 cells into islet-like RNAKT-15, microarray and quantitative proteomics were performed. Our analysis of differential proteomic and mRNA expression has resulted in a greater understanding of the molecular functions that are involved in beta-cell differentiation and insulin synthesis and release.
ISSN
1535-3893
Language
English
URI
https://hdl.handle.net/10371/77409
DOI
https://doi.org/10.1021/pr800765t
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse