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Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics

Cited 18 time in Web of Science Cited 19 time in Scopus
Authors
Kim, Jin-Moo; Park, Byung-Lae; Park, Se-Min; Lee, Shin-Hwa; Jung, Seok; Uh, Soo-Taek; Choi, Jae-Sung; Kim, Mi-Kyeong; Cho, Sang Heon; Park, Choon-Sik; Shin, Hyoung Doo; Chang, Hun Soo; Park, Hae-Sim; Choi, Byoung Whui; Choi, Inseon S.; Kim, Yong-Hoon; Park, Jong Sook; Lee, Eun Hee; Kim, Myung-Ok
Issue Date
2010-07
Publisher
FUTURE MEDICINE LTD
Citation
PHARMACOGENOMICS; Vol.11 7; 951-958
Keywords
arylamine N-acetyltransferaseaspirin-induced asthmacysteinyl leukotrieneSNP
Abstract
Aims: Cysteinyl leukotrienes are inactivated by acetyl coenzyme A-dependent N-acetyltransferase (NAT). Thus, functional alterations of the NAT gene may contribute to the risk of aspirin-intolerant asthma. Materials & methods: Asthmatics (n = 438) were categorized into aspirin-intolerant asthma (15% or greater decrease in the forced expiratory volume in 1 s or cutaneous reactions, n = 170) or aspirin-tolerant asthma (n = 268) groups. In total, 14 polymorphisms of the NAT2 gene were genotyped by a single-base extension method. Results: The distributions of all loci of the 14 SNPs were in Hardy-Weinberg equilibrium (p > 0.05). Among the 14 SNPs, six common SNPs (minor allele frequency >5%) in a Korean population were used for haplotype construction and further statistical analysis. The logistic regression analysis demonstrated that NAT2 -9246G>C and haplotype 2 (TCACGG) were significantly associated with the risk of aspirin-intolerant asthma. The rare allele frequencies of the SNP and Ht2 were significantly higher in the aspirin-intolerant asthma group than in the aspirin-tolerant asthma group (pwrr = 0.03 and IV)" = 0.02 in codominant model). Conclusion: In a large genetic epidemiology study of aspirin-intolerant asthma in a Korean population, genetic polymorphisms of NAT2 were found to be related to a risk of aspirin hypersensitivity among asthmatics.
ISSN
1462-2416
Language
English
URI
https://hdl.handle.net/10371/77436
DOI
https://doi.org/10.2217/PGS.10.65
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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