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Identification of autoantibody against beta-amyloid peptide in the serum of elderly

Cited 14 time in Web of Science Cited 15 time in Scopus
Authors
Sohn, Ji-Hoon; So, Jung On; Hong, Hyun Joo; Kim, Jong Won; Kim, Manho; Nam, Eunjoo; Kim, Young Ho; Mook-Jung, Inhee; Ha, Hee Jin; Kim, Hee; Na, Duk Ryul
Issue Date
2009-01
Publisher
FRONTIERS IN BIOSCIENCE INC
Citation
FRONTIERS IN BIOSCIENCE; Vol.14 ; 3879-3883
Keywords
Beta-Amyloid PeptideAnti- A-betaAgingAlzheimer`s diseaseautoantibody
Abstract
Alzheimer`s disease (AD) is characterized by two major neurological features: amyloid deposits and neurofibrillary tangles in the brain. According to the amyloid cascade hypothesis, accumulation of amyloid-beta peptide (A-beta) plays a central role in the pathogenesis of AD. Several lines of evidence suggest that antibodies against A-beta play a protective role in the neuropathology of AD. In this study, we describe the purification of an autoantibody against A-beta from human serum using affinity purification method. The purified autoantibody recognized A-beta deposits in the brain of aged Tg2676 mice, an animal model of AD. The serum levels of anti-A-beta autoantibody correlated inversely with age in both AD patients and control non-demented elderly subjects. Furthermore, the levels were significantly lower in AD patients compared with the age-matched control subjects. It is the first time to show the identification of endogenous anti-A-beta autoantibody in human serum and suggesting that serum levels of anti-A-beta autoantibody might be a good biomarker for AD patients.
ISSN
1093-9946
Language
English
URI
http://hdl.handle.net/10371/77465
DOI
https://doi.org/10.2735/3496
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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