S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Neurology (신경과학교실) Journal Papers (저널논문_신경과학교실)
Identification of autoantibody against beta-amyloid peptide in the serum of elderly
- Sohn, Ji-Hoon; So, Jung On; Hong, Hyun Joo; Kim, Jong Won; Kim, Manho; Nam, Eunjoo; Kim, Young Ho; Mook-Jung, Inhee; Ha, Hee Jin; Kim, Hee; Na, Duk Ryul
- Issue Date
- FRONTIERS IN BIOSCIENCE INC
- FRONTIERS IN BIOSCIENCE; Vol.14 ; 3879-3883
- Alzheimer`s disease (AD) is characterized by two major neurological features: amyloid deposits and neurofibrillary tangles in the brain. According to the amyloid cascade hypothesis, accumulation of amyloid-beta peptide (A-beta) plays a central role in the pathogenesis of AD. Several lines of evidence suggest that antibodies against A-beta play a protective role in the neuropathology of AD. In this study, we describe the purification of an autoantibody against A-beta from human serum using affinity purification method. The purified autoantibody recognized A-beta deposits in the brain of aged Tg2676 mice, an animal model of AD. The serum levels of anti-A-beta autoantibody correlated inversely with age in both AD patients and control non-demented elderly subjects. Furthermore, the levels were significantly lower in AD patients compared with the age-matched control subjects. It is the first time to show the identification of endogenous anti-A-beta autoantibody in human serum and suggesting that serum levels of anti-A-beta autoantibody might be a good biomarker for AD patients.
- Files in This Item: There are no files associated with this item.