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Identification of autoantibody against beta-amyloid peptide in the serum of elderly
Cited 15 time in
Web of Science
Cited 17 time in Scopus
- Authors
- Issue Date
- 2009-01
- Publisher
- FRONTIERS IN BIOSCIENCE INC
- Citation
- FRONTIERS IN BIOSCIENCE; Vol.14 ; 3879-3883
- Keywords
- Beta-Amyloid Peptide ; Anti- A-beta ; Aging ; Alzheimer`s disease ; autoantibody
- Abstract
- Alzheimer`s disease (AD) is characterized by two major neurological features: amyloid deposits and neurofibrillary tangles in the brain. According to the amyloid cascade hypothesis, accumulation of amyloid-beta peptide (A-beta) plays a central role in the pathogenesis of AD. Several lines of evidence suggest that antibodies against A-beta play a protective role in the neuropathology of AD. In this study, we describe the purification of an autoantibody against A-beta from human serum using affinity purification method. The purified autoantibody recognized A-beta deposits in the brain of aged Tg2676 mice, an animal model of AD. The serum levels of anti-A-beta autoantibody correlated inversely with age in both AD patients and control non-demented elderly subjects. Furthermore, the levels were significantly lower in AD patients compared with the age-matched control subjects. It is the first time to show the identification of endogenous anti-A-beta autoantibody in human serum and suggesting that serum levels of anti-A-beta autoantibody might be a good biomarker for AD patients.
- ISSN
- 1093-9946
- Language
- English
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