Browse

CD4+T-CELL-DEPENDENT GOBLET CELL PROLIFERATION AND EXPULSION OF GYMNOPHALLOIDES SEOI FROM THE INTESTINE OF C57BL/6 MICE

Cited 13 time in Web of Science Cited 12 time in Scopus
Authors
Guk, Sang-Mee; Lee, Jun-Haeng; Kim, Hyo-Jin; Kim, Won-Hee; Chai, Jong-Yil; Shin, Eun-Hee
Issue Date
2009-06
Publisher
AMER SOC PARASITOLOGISTS
Citation
JOURNAL OF PARASITOLOGY; Vol.95 3; 581-590
Abstract
Mechanisms for the spontaneous worm expulsion from the host intestine are not well understood in gastrointestinal trematode models. We studied the role of CD4+ T-helper cells in mediating goblet cell hyperplasia and expulsion of Gymnophalloides seoi from the intestines of C57BL/6 (resistant) and ICR (susceptible) mice. C57BL/6 mice expelled all G. seoi. worms within 4 days post-infection (PI), while ICR mice did not completely expel worms until day 7 PI. This difference in worm expulsion was associated with high numbers of mucosal goblet cells in C57BL/6 mice along with alteration of the mucin quality, with changes in the terminal sugar chain and high levels of IL-4 and IL-5 mRNA expression in mesenteric lymph nodes. Adoptive transfer Of mucosal CD4+ T-helper cells to syngeneic mice elicited strong goblet cell hyperplasia and a notably accelerated worm expulsion. However, this T-helper cell transfer had no relationship with the alteration of mucin quality. The results showed that CD4+ T-helper cells play an important role as a mediator of goblet cell hyperplasia, but not for functional activation of goblet cells. It is Suggested that both T-cell dependent and independent mechanisms operate for expulsion of G. seoi front the mouse intestine.
ISSN
0022-3395
Language
English
URI
https://hdl.handle.net/10371/77564
DOI
https://doi.org/10.1645/GE-1807.1
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Parasitology and Tropical Medicine (기생충학전공)Journal Papers (저널논문_기생충학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse