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Tumor Size and Age Predict the Risk of Malignancy in Hurthle Cell Neoplasm of the Thyroid and Can Therefore Guide the Extent of Initial Thyroid Surgery

Cited 19 time in Web of Science Cited 16 time in Scopus
Authors
Kim, Tae Hyuk; Lim, Jung Ah; Ahn, Hwa Young; Lee, Eun Kyung; Kim, Kyung Won; Park, Young Joo; Kim, Kwang Hyun; Cho, Bo Youn; Youn, Yeo Kyu; Park, Do Joon; Choi, Yun-Hee; Min, Hye Sook
Issue Date
2010-11
Publisher
MARY ANN LIEBERT INC
Citation
THYROID; Vol.20 11; 1229-1234
Abstract
Background: The majority of patients having a diagnosis of Hurthle cell neoplasm (HCN) on fine-needle aspiration (FNA) of a thyroid nodule have a diagnostic thyroid lobectomy to make the final diagnosis. If the nodule is malignant, they require a completion thyroidectomy. The objective of this study was to devise a simple clinical scheme capable of predicting malignancy in patients with cytologic diagnosis of HCN and, therefore, guide the extent of initial thyroid surgery. Methods: A total of 57 patients who underwent thyroid surgery after an FNA diagnosis of HCN were retrospectively studied. The patients were examined for clinical features, preoperative imaging studies, and pathology reports. The risk of malignancy was calculated using a multiple logistic regression model. Results: The overall rate of malignancy in patients with HCN was 46% (26/57). The predictors of malignancy based on multiple logistic regression analysis were tumor size >1.5 cm (odds ratio [95% confidence interval] 8.0 [1.9-33.4]) and patient age >45 years (odds ratio [95% confidence interval] 2.3 [0.6-8.6]). In patients with nodules larger than 1.5 cm, the predicted probability of malignancy was greater in patients over 45 years than in younger patients (65% for >45 years vs. 44% for <= 45 years). In patients with a nodule 1.5 cm or less, the probability of malignancy was relatively low and not significantly different between the two age categories (18% for >45 years vs. 10% for <= 45 years). Conclusions: This study suggests that tumor size and age can be integrated into decision making for patients with an FNA diagnosis of HCN to facilitate patient selection for surgical referral and, particularly, to determine in which patients a thyroidectomy rather than a lobectomy should be the initial surgery.
ISSN
1050-7256
Language
English
URI
https://hdl.handle.net/10371/77646
DOI
https://doi.org/10.1089/thy.2009.0443
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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