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Differentiating radiation necrosis from tumor recurrence in high-grade gliomas: Assessing the efficacy of (18)F-FDG PET, (11)C-methionine PET and perfusion MRI

Cited 102 time in Web of Science Cited 109 time in Scopus
Authors
Kim, Yong Hwy; Oh, So Won; Lim, You Jung; Park, Chul-Kee; Kang, Keon Wook; Chang, Kee Hyun; Jung, Hee-Won; Lee, Se-Hoon
Issue Date
2010-11
Publisher
ELSEVIER SCIENCE BV
Citation
CLINICAL NEUROLOGY AND NEUROSURGERY; Vol.112 9; 758-765
Keywords
High-grade gliomaRecurrenceRadiation necrosisPETPerfusion MRI
Abstract
Purpose: The authors analyzed the characteristics of perfusion magnetic resonance imaging (MRI), (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and (11)C-methionine (MET) PET to compare the efficacies of these modalities in making the distinction between radiation necrosis and tumor recurrence of high-grade glioma. Patients and methods: Ten patients were evaluated with dynamic susceptibility contrast perfusion MRI, (11)C-MET PET and (18)F-FDG PET to visualize gadolinium-enhanced lesions during the post-radiation follow-up period. In the perfusion MRI, four regions of interest (ROIs) were identified and average values were calculated. A reference ROI of the same size was defined in the contralateral white matter to obtain the relative cerebral blood volume (rCBV). After coregistering the PET images with the MRI, we measured the maximum uptake values of the lesion and of the contralateral cerebral white matter as reference area to calculate the L(max)/R(max) ratio. Results: The rCBV was higher in the recurrence group than in the necrosis group (p = 0.010). There was no difference between groups in terms of the L(max)/R(max) ratio as derived from the 18F-FDG and (11)C-MET PET. Conclusion:A quantitative rCBV as calculated from a perfusion MRI scan might be superior to the L(max)/R(max) ratio as derived from (18)F-FDG and (11)C-MET PET in order to distinguish a recurrence of high-grade glioma from radiation necrosis. (C) 2010 Elsevier B.V. All rights reserved.
ISSN
0303-8467
Language
English
URI
http://hdl.handle.net/10371/77647
DOI
https://doi.org/10.1016/j.clineuro.2010.06.005
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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