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Long-Term Surgical Outcomes of Temporal Lobe Epilepsy Associated With Low-Grade Brain Tumors

Cited 42 time in Web of Science Cited 46 time in Scopus
Authors
Phi, Ji Hoon; Kim, Seung-Ki; Cho, Byung-Kyu; Lee, Seo Young; Park, Sung-joon; Kim, Ki Joong; Chung, Chun Kee; Lee, Sang Kun; Park, Su Yeon
Issue Date
2009-12-15
Publisher
JOHN WILEY & SONS INC
Citation
CANCER; Vol.115(24); 5771-5779
Keywords
brain tumortemporal lobe epilepsytailored resectionseizure controltumor control
Abstract
BACKGROUND: Tumor-related temporal lobe epilepsy (TLE) has a high likelihood of medical intractability and requires surgical treatment. The aims of this study were to analyze the long-term surgical outcomes of and to present appropriate surgical strategies for tumor-related TLE. METHODS: The clinical data of 87 consecutive patients diagnosed with tumor-related TLE were analyzed. The median age at surgery was 22 years. Sixteen patients had a tumor confined to the amygdala or the parahippocampal gyrus, and 10 of them received a tailored lesionectomy without hippocampectomy. The surgical outcome was evaluated based on 3 aspects: seizure control, tumor control, and discontinuation of antiepileptic drugs (AEDs). RESULTS: The actuarial seizure and tumor control rates at the fifth year postoperatively were 79% and 90%, respectively. Seizure control was highly correlated with tumor control. The following factors were found to be significantly associated with poor seizure control: duration of epilepsy >10 years, presence of a remote focus on surface electroencephalography, and incomplete tumor removal. The actuarial AED maintenance rates were 47% at the second year and 11% at the fifth year. The median time to AED discontinuation was 22 months. A younger age at surgery was found to be significantly associated with an increased chance of AED discontinuation. Tailored resection focusing on the tumor resulted in a favorable outcome, even for tumors confined to the amygdala or the parahippocampal gyrus. CONCLUSIONS: Surgical treatment of tumor-related TLE resulted in long-term seizure control in the majority of patients. Maximal tumor removal can be recommended for tumor-related TLE. Cancer 2009;115:5771-9. (C) 2009 American Cancer Society.
ISSN
0008-543X
Language
English
URI
https://hdl.handle.net/10371/77704
DOI
https://doi.org/10.1002/cncr.24666
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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