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Time-dependent differential gene expression in lysophosphatidic acid-treated young and senescent human diploid fibroblasts

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Authors
Rhim, Ji-Heon; Jang, Ik-Soon; Choi, Jong-Soon; Kwon, Hyun Jin; Park, Sang Chul; Yeo, Eui-Ju
Issue Date
2009-09
Publisher
ELSEVIER IRELAND LTD
Citation
MECHANISMS OF AGEING AND DEVELOPMENT; Vol.130(9); 648-651
Keywords
Differential gene expressionSenescent HDFscDNA microarray analysisHuman diploid fibroblastsLysophosphatidic acid
Abstract
The gene expression profiles of lysophosphatidic acid (LPA)-treated young and senescent human diploid fibroblasts (HDFs) were examined using cDNA microarray analysis. The expression of some genes, including EGR 1/3 and MRRF, was controlled by LPA similarly in young and senescent cells, showing a typical time-dependent up-and-down expression profile. In contrast, some other genes, including DUSP6, CYR61, and F3, showed sustained upregulation in senescent HDFs later after LPA treatment. These genes might be involved in altered LPA responsiveness during the aging process.
ISSN
0047-6374
Language
English
URI
https://hdl.handle.net/10371/77734
DOI
https://doi.org/10.1016/j.mad.2009.06.007
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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