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Does vitamin D status contribute to caveolin-1-mediated insulin sensitivity in skeletal muscle? Reply to Boucher BJ [letter]
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- Authors
- Issue Date
- 2009-10
- Publisher
- SPRINGER
- Citation
- DIABETOLOGIA; Vol.52; no.10; 2241-2243
- Abstract
- To the Editor: Vitamin D deficiency is a significant risk
factor for type 2 diabetes, although the effect of vitamin D
supplementation for treatment of type 2 diabetes is still
under debate [1–3]. It has also been reported that vitamin D
receptor (VDR) is present in caveolae [4]. Dr Boucher has
therefore posed two important questions [5] in response to
our study [6] on caveolin-1 in an ageing-dependent nonobese
type 2 diabetic animal model (JYD mouse): (1)
whether insulin sensitivity could be improved by vitamin D
in JYD mice; and (2) whether such an improvement might
be due to an upregulation of caveolin-1 production affected
by vitamin D.
- ISSN
- 0012-186X
- Language
- English
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