S-Space College of Medicine/School of Medicine (의과대학/대학원) Pathology (병리학전공) Journal Papers (저널논문_병리학전공)
Expression of MMP-2, MMP-9, and Urokinase-Type Plasminogen Activator in Cervical Intraepithelial Neoplasia
- No, Jae Hong; Jo, Hoenil; Kim, Su-Hyeong; Park, In-Ae; Lee, Chae Hyeong; Kim, Jae Weon; Kang, Soon-Beom; Song, Yong-Sang; Park, Noh-Hyun; Han, Seung-Su; Kang, Daehee
- Issue Date
- BLACKWELL PUBLISHING
- NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS; Vol.1171 ; 100-104
- cervical intraepithelial neoplasia; matrix metalloproteinase; urokinase-type plasminogen activator
- Matrix metalloproteinase-2 (MMP-2), MMP-9, and urokinase-type plasminogen activator (uPA) are important factors for cancer invasion and metastasis, degrading the extracellular matrix. They are also associated with angiogenesis. Angiogenic phenotype is another feature of high-grade cervical intraepithelial neoplasia (CIN). However, their associations with the progression of low-grade CIN to high-grade CIN are unexplored. We investigated whether these proteolytic enzyme expressions correlate with the progression of CIN. A total of 39 paraffin-embedded specimens from 10 patients with CIN grade 1, nine with CIN grade 2, and 20 with CIN grade 3 were assessed immunohistochemically by specific antibodies against MMP-2, MMP-9, and uPA. MMP-9 expression was higher in CIN 3 lesions (47.4%) than in CIN 1 (22.2%) and CIN 2 (20.2%) lesions, although the difference failed to reach statistical significance. The expression level of uPA and MMP-2 was not associated with the grade of CIN lesions. Interestingly, we found a significant association between expressions of uPA and MMP-2 (P = 0.028). Our results suggest that MMP-9 might play a role in the progression of CIN.
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