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Doublecortin-Immunoreactive Neuronal Precursors in the Dentate Gyrus of Spontaneously Hypertensive Rats at Various Age Stages: Comparison with Sprague-Dawley Rats

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Hwang, In Koo; Yoon, Yeo Sung; Choi, Jung Hoon; Yoo, Ki-Yeon; Yi, Sun Shin; Chung, Dae Won; Kim, Hyun-Jin; Kim, Chung-Seop; Do, Seon-Gil; Sung, Je Kyeong; Lee, In Se; Won, Moo-Ho
Issue Date
2008
Publisher
Japanese Society of Veterinary Science
Citation
J. Vet. Med. Sci. 70: 373-377
Keywords
developmentdoublecortinneurogenesisspontaneously hypertensive rat
Abstract
Spontaneously hypertensive rats (SHRs) are widely accepted in medical research because this model has been used for studies in neurodegenerative diseases such as vascular dementia and stroke. In the present study, we observed newly generated neuronal precursors using doublecortin (DCX, a marker of neural proliferation and differentiation) in the subgranular zone of the dentate gyrus in SHRs compared to Sprague-Dawley rats (SDRs) at various age stages. DCX immunoreactivity, immunoreactive cell numbers and its protein level in the dentate gyrus of the SHRs were higher than those in the SDRs at postnatal month 1 (PM 1). At PM 8, DCX immunoreactivity, immunoreactive cell numbers and protein levels in both groups were markedly decreased compared to those at PM 1; however, they were higher than those in the SDRs. They were decreased in the both groups with age: DCX immunoreactive cells in the SDRs were few at PM 12. Our results indicate that newly generated neuronal precursors are more abundant in SHRs than in SDRs during their life.
ISSN
0916-7250 (online)
1347-7439 (print)
Language
English
URI
http://hdl.handle.net/10371/7784
DOI
https://doi.org/10.1292/jvms.70.373
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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