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Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver

Cited 5 time in Web of Science Cited 6 time in Scopus
Authors
Ju, Sun-Young; Cho, Kyung-Ah; Cho, Su Jin; Jung, Yun-Jae; Seoh, Ju-Young; Ryu, Kyung-Ha; Han, Ho-Seong; Woo, So-Youn
Issue Date
2009-01
Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation
CELL BIOLOGY INTERNATIONAL; Vol.33(1); 31-35
Keywords
Bone marrow cellsHypoxiaCell migrationSDF-1
Abstract
Restricted numbers and poor regenerative properties limit the use of adult stem cells. We tested the effect of hypoxic treatment as a method by which to increase cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations of 0.1, 3, and 20% for 24 h. After hypoxic treatment, BMCs of apoptotic fraction were decreased. The expression of CXCR4 was noticeably increased in the hypoxia-treated BMCs and their migration in response to SDF-1 alpha was enhanced compared with cells cultured under normoxic condition. Hypoxic BMCs had a higher degree of engraftment to the CCl(4)-injured liver than the normoxic cells. Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells as well as in enhancing cellular migration to SDF-1 alpha, the chemokine which binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl(4) damaged liver. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
ISSN
1065-6995
Language
English
URI
http://hdl.handle.net/10371/77840
DOI
https://doi.org/10.1016/j.cellbi.2008.10.002
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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