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Flavonoids inhibit the AU-rich element binding of HuC

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dc.contributor.authorKwak, Hojoong-
dc.contributor.authorJeong, Kyung-Chae-
dc.contributor.authorChae, Min-Ju-
dc.contributor.authorKim, Soo-Youl-
dc.contributor.authorPark, Woong-Yang-
dc.date.accessioned2012-07-03T00:44:46Z-
dc.date.available2012-07-03T00:44:46Z-
dc.date.issued2009-01-31-
dc.identifier.citationBMB REPORTS; Vol.42 1; 41-46ko_KR
dc.identifier.issn1976-6696-
dc.identifier.urihttps://hdl.handle.net/10371/78160-
dc.description.abstractPost-transcriptional regulation of mRNA stability by Hu proteins is an important mechanism for tumorigenesis. We focused on the molecular interactions between the HuC protein and AU-rich elements (AREs) to find chemical inhibitors of RNA-protein interactions using RNA electrophoretic mobility shift assay with non-radioactive probes. Screening of 52 natural compounds identified 14 candidate compounds that displayed potent inhibitory activity. Six (quercetin, myricetin, (-)-epigallocatechin gallate, ellagic acid, (-)-epicatechin gallate, and rhamnetin) were categorized as phytochemicals, and their IC(50) values were low (0.2-1.8 mu M).ko_KR
dc.description.sponsorshipThis work was supported by the BK21 program of the Korea
Ministry of Education and Human Resources Development
and by grant No. 03-2008-017 from the SNUH Research fund.		ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGYko_KR
dc.subjectAU-rich elementko_KR
dc.subjectNatural compoundsko_KR
dc.subjectHuCko_KR
dc.subjectElectrophoretic mobility shift assayko_KR
dc.subjectFlavonoidsko_KR
dc.titleFlavonoids inhibit the AU-rich element binding of HuCko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor곽호중-
dc.contributor.AlternativeAuthor정경채-
dc.contributor.AlternativeAuthor채민주-
dc.contributor.AlternativeAuthor김수열-
dc.contributor.AlternativeAuthor박웅양-
dc.citation.journaltitleBMB REPORTS-
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dc.description.tc5-
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