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Flavonoids inhibit the AU-rich element binding of HuC
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- Authors
- Issue Date
- 2009-01-31
- Citation
- BMB REPORTS; Vol.42 1; 41-46
- Keywords
- AU-rich element ; Natural compounds ; HuC ; Electrophoretic mobility shift assay ; Flavonoids
- Abstract
- Post-transcriptional regulation of mRNA stability by Hu proteins is an important mechanism for tumorigenesis. We focused on the molecular interactions between the HuC protein and AU-rich elements (AREs) to find chemical inhibitors of RNA-protein interactions using RNA electrophoretic mobility shift assay with non-radioactive probes. Screening of 52 natural compounds identified 14 candidate compounds that displayed potent inhibitory activity. Six (quercetin, myricetin, (-)-epigallocatechin gallate, ellagic acid, (-)-epicatechin gallate, and rhamnetin) were categorized as phytochemicals, and their IC(50) values were low (0.2-1.8 mu M).
- ISSN
- 1976-6696
- Language
- English
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