S-Space College of Medicine/School of Medicine (의과대학/대학원) Pharmacology (약리학전공) Journal Papers (저널논문_약리학전공)
BT-11 Improves Stress-Induced Memory Impairments Through Increment of Glucose Utilization and Total Neural Cell Adhesion Molecule Levels in Rat Brains
- Shin, Ki Young; Won, Beom Young; Heo, Chaejeong; Kim, Hee Jin; Park, Cheol Hyoung; Kim, Hye-Sun; Lee, Hyung Gun; Cho, Zang-Hee; Suh, Yoo-Hun; Lee, Sang Hyung; Kim, Young-Bo; Kim, Seonghan; Jang, Dong-Pyo
- Issue Date
- JOURNAL OF NEUROSCIENCE RESEARCH; Vol.87 1; 260-268
- In Oriental medicine, roots of Polygala tenuifolia Willde-now have been known to be an important herb that exhibits sedative effects in insomnia, palpitation with anxiety, restlessness, and disorientation in humans. We previously reported that BT-11, extracted from those roots, improved scopolamine-induced amnesia in rats and inhibited acetylcholinesterase activities in vitro. Therefore, we proposed that BT-11 could remedy stress-induced memory deficits in rats. In this study, the stress-induced memory impairments in rats were significantly reversed almost to the control level by BT-11 treatment. To seek an active component of BT-11 that plays an important role in antipsychotic effects, we compared BT-11 with 3,4,5-trimethoxycinnamic acid (TMCA), which is a constituent of those root extracts. However, the effects of TMCA were less or were not consistent with those of BT-11 in some of tests. In perticular, BT-11 reversed the stress-induced reduction of glucose utilization by [(18)fluorodeoxyglucose] FDG-PET and the levels of neural cell adhesion molecule (NCAM) in rat brains to the control levels, whereas TMCA did not. Therefore, BT-11 improved stress-induced memory impairments through increment of glucose utilization and total NCAM levels in rat brains. In conclusion, BT-11 may be strongly effective against stress-induced amnesia in rats, through the combined effects of TMCA and other active components of BT-11. (C) 2008 Wiley-Liss, Inc.
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