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The Effect of Curculigoside on the Expression of Matrix Metalloproteinase-1 in Cultured Human Skin Fibroblasts
Cited 17 time in
Web of Science
Cited 21 time in Scopus
- Authors
- Issue Date
- 2009-10
- Publisher
- PHARMACEUTICAL SOC KOREA
- Citation
- ARCHIVES OF PHARMACAL RESEARCH; Vol.32 10; 1433-1439
- Keywords
- Curculigo orchioides G. ; Matrix metalloproteinase-1 ; Type-1 procollagen ; Cycloartane saponin ; Amaryllidaceae ; Phenolic glycoside ; Curculigoside
- Abstract
- The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-beta-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.
- ISSN
- 0253-6269
- Language
- English
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