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Biology of melanogenesis and the search for hypopigmenting agents

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Authors
Park, Kyoung-Chan; Huh, Sun Young; Choi, Hye Ryung; Kim, Dong-Seok
Issue Date
2010-06
Publisher
TAIWANESE DERMATOLOGICAL ASSOC
Citation
DERMATOLOGICA SINICA; Vol.28(2); 53-58
Keywords
MechanismMelaninTyrosinase
Abstract
Increased production and accumulation of melanin are characteristics of a large number of skin diseases, including melasma, post-inflammatory hyperpigmentation and lentigo. A number of clinical agents can reduce normal or abnormal pigmentation, but none of these have achieved satisfactory effects. This review discusses the mechanisms behind the different approaches. Tyrosinase is a pivotal enzyme in melanin synthesis. The majority of whitening or lightening agents act by specifically reducing the activity of tyrosinase via several mechanisms: (1) prior to melanin synthesis (interfering with its transcription and/or glycosylation); (2) during melanin synthesis (tyrosinase inhibition, peroxidase inhibition and reduction of byproducts); and (3) after melanin synthesis (tyrosinase degradation, inhibition of melanosome transfer, acceleration of skin turnover). Additional melanogenesis-associated mechanisms are also discussed.
ISSN
1027-8117
Language
English
URI
http://hdl.handle.net/10371/78347
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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