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Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines

Cited 25 time in Web of Science Cited 26 time in Scopus
Authors
Park, Seok-Woo; Kim, Hyo-Sun; Hah, Jeong-Whun; Jeong, Woo-Jin; Sung, Myung-Whun; Kim, Kwang-Hyun
Issue Date
2010-10
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
ANTI-CANCER DRUGS; Vol.21 9; 823-830
Keywords
celecoxibtumor killinghead and neck cancermitogen-activated protein kinase
Abstract
It has been observed that several cyclooxygenase-2 (COX-2) inhibitory chemicals might inhibit proliferation of various cancer cells through COX-2-independent action. We also identified that celecoxib more selectively kills cell lines derived from head and neck squamous cell carcinoma (HNSCC) than its non-cancerous counterparts, irrespective of COX-2 expression. Herein, we investigated whether the regulation of mitogen-activated protein kinases activity might be one of the main mechanisms related to a conspicuous COX-2-independent tumor-killing effect of celecoxib in HNSCC cell lines. We assessed the effect of celecoxib on extracellular signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase activity by a transcription factor activation assay then evaluated, if these factors might be involved in the COX-2-independent tumor-killing effect of celecoxib by blocking their activity. We found that the blocking activation of ERK and/or p38 could reverse the celecoxib-induced cell growth inhibition by 50-80% in HNSCC cell lines, but it was not tested in cancer cells of other types. In conclusion, our study suggests that most COX-2-independent tumor-killing action of celecoxib is mediated by the upregulation of ERK and/or p38 activity in HNSCC cells. These results encourage investigation on the underlying mechanisms and detailed outcomes of mitogen-activated protein kinases activation by celecoxib more concisely, for using its excellent tumor-killing effect more safely in the clinical field of cancer treatment. Anti-Cancer Drugs 21:823-830 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
ISSN
0959-4973
Language
English
URI
http://hdl.handle.net/10371/78464
DOI
https://doi.org/10.1097/CAD.0b013e32833dada8
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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