S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Aripiprazole in the Treatment of Early-Onset Schizophrenia Spectrum Disorder: A Case Series in Korean Children and Adolescents
Cited 1 time in Web of Science Cited 0 time in Scopus
- Issue Date
- CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL; Vol.70(2); 173-183
- OBJECTIVE: The aim of this case series was to assess the effectiveness and tolerability of aripiprazole in Korean children and adolescents with early-onset schizophrenia spectrum (EOSS) disorder. METHODS: The medical records of aripiprazole-treated patients with EOSS were retrospectively reviewed. Changes in illness severity were measured using the Clinical Global Impression-Severity of Illness (CGI-S) and Clinical Global Impression-Improvement (CGI-I) scales. RESULTS: Data from 22 children and adolescents were included (12 girls, 10 boys; mean [SDI age, 14.0 [2.4] years). The mean (SD) dosage of aripiprazole was 19.8 (9.4) mg/d (median, 18.7 mg/d; mode, 15, 30 mg/d), and the range of treatment duration was 21 to 838 days. Mean (SD) CGI-S score improved significantly from baseline to end point (from 5.7 [0.7] to 4.3 [1.4]; P < 0.001). Based on changes in chart-extracted CGI-I scores, significantly greater improvement was associated with negative symptoms compared with positive symptoms (U = 25.5; P = 0.028; r = -0.47). Aripiprazole was discontinued due to insufficient effect in 5 patients (22.7%) and treatment-emergent adverse events In 3 patients (13.6%). CONCLUSION: The results from this small Study suggest that aripiprazole was moderately effective in reducing psychotic symptoms In these Korean children and adolescents with EOSS.
- Files in This Item: There are no files associated with this item.
- Appears in Collections:
- College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.