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Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder

Cited 76 time in Web of Science Cited 80 time in Scopus
Authors
Jang, Joon Hwan; Kim, Jae-Hun; Jung, Wi Hoon; Choi, Jung-Seok; Lee, Jong-Min; Kang, Do-Hyung; Kwon, Jun Soo; Choi, Chi-Hoon; Jung, Myung Hun
Issue Date
2010-05-03
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS; Vol.474(3); 158-162
Keywords
Obsessive-compulsive disorderFunctional connectivityResting stateDefault mode network
Abstract
Obsessions and compulsions mediated by cognitive inflexibility might be associated with abnormal resting state functional connectivity in the default mode network (DMN) that represents intrinsically generated neuronal activity. It was hypothesized that decreased functional connectivity in the DMN would occur in components of fronto-subcortical circuits in patients with obsessive-compulsive disorder (OCD). Twenty-two unmedicated OCD patients and 22 age- and sex-matched healthy controls received resting state functional scanning runs. The posterior cingulate cortex (PCC) region was chosen as the seed region for the connectivity analysis. Correlations between temporal connectivity with the seed region and scores on clinical measures and obsessive-compulsive symptom dimensions were also assessed. OCD patients demonstrated less functional connectivity within the DMN in the anterior cingulate cortex, middle frontal gyrus, and putamen compared to controls. The functional connectivity to the PCC seed region in OCD patients was in the direction opposite to that in the prefrontal areas with regard to scores on cleaning and obsessions/checking dimensions of OCD. These data provide evidence for fronto-subcortical dysfunction in OCD. Results from this study also support the notion that OCD is a heterogeneous disorder mediated by distinct circuits.
ISSN
0304-3940
Language
English
URI
http://hdl.handle.net/10371/78594
DOI
https://doi.org/10.1016/j.neulet.2010.03.031
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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