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Nuclear Factor-Kappa B Inhibition Reduces Markedly Cell Proliferation in Epstein-Barr Virus-Infected Stomach Cancer, But Affects Variably in Epstein-Barr Virus-Negative Stomach Cancer

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Jeong, Jin-Yong; Woo, Jun Hee; Kim, Yang Soo; Choi, Sangho; Kil, Seol-Ryoung; Lee, Byung Lan; Nam, Byung-Ho; Chang, Mee Soo; Kim, Woo Ho; Kim, Chul Woo; Lee, Sang Oh
Issue Date
2010-02
Publisher
TAYLOR & FRANCIS INC
Citation
CANCER INVESTIGATION; Vol.28, No.2; 113-119
Keywords
Epstein-Barr virusStomach neoplasmBeta-cateninNuclear factor-kappa B
Abstract
Nuclear factor-kappa B (NF-kappa B) inhibition by NF-kappa B p65-specific siRNA induced a near-cessation of cell proliferation in EBV-positive stomach cancer cell, and notably diminished cell proliferation in EBV- positive Raji lymphoma cell. In EBV-negative stomach cancer cells, NF-kappa B inhibition affected variably cell proliferation. Regardless of cell type, NF-kappa B inhibition suppressed antiapoptotic function of NF-kappa B, and tended to promote the nuclear accumulation of beta-catenin. This inverse relationship between NF-kappa B and beta-catenin was evident in 120 resected gastric carcinomas. Conclusively, NF-kappa B inhibition may be beneficial in the therapy of EBV-positive stomach cancer, but influence variously EBV-negative stomach cancer.
ISSN
0735-7907
Language
English
URI
http://hdl.handle.net/10371/78683
DOI
https://doi.org/10.3109/07357900903095730
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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