S-Space College of Medicine/School of Medicine (의과대학/대학원) Anatomy (해부학전공) Journal Papers (저널논문_해부학전공)
Nuclear Factor-Kappa B Inhibition Reduces Markedly Cell Proliferation in Epstein-Barr Virus-Infected Stomach Cancer, But Affects Variably in Epstein-Barr Virus-Negative Stomach Cancer
- Jeong, Jin-Yong; Woo, Jun Hee; Kim, Yang Soo; Choi, Sangho; Kil, Seol-Ryoung; Lee, Byung Lan; Nam, Byung-Ho; Chang, Mee Soo; Kim, Woo Ho; Kim, Chul Woo; Lee, Sang Oh
- Issue Date
- TAYLOR & FRANCIS INC
- CANCER INVESTIGATION; Vol.28, No.2; 113-119
- Nuclear factor-kappa B (NF-kappa B) inhibition by NF-kappa B p65-specific siRNA induced a near-cessation of cell proliferation in EBV-positive stomach cancer cell, and notably diminished cell proliferation in EBV- positive Raji lymphoma cell. In EBV-negative stomach cancer cells, NF-kappa B inhibition affected variably cell proliferation. Regardless of cell type, NF-kappa B inhibition suppressed antiapoptotic function of NF-kappa B, and tended to promote the nuclear accumulation of beta-catenin. This inverse relationship between NF-kappa B and beta-catenin was evident in 120 resected gastric carcinomas. Conclusively, NF-kappa B inhibition may be beneficial in the therapy of EBV-positive stomach cancer, but influence variously EBV-negative stomach cancer.
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