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Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens

Cited 5 time in Web of Science Cited 6 time in Scopus
Authors
Kang, Hee Gyung; Lee, Jung Eun; Yang, Seung Hee; Lee, Se Han; Strom, Terry B.; Lee, Dong-Sup; Kim, Yon Su; Oh, Keunhee; Gao, Wenda
Issue Date
2010-04
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
IMMUNOLOGY; Vol.129(4); 567-577
Keywords
clonal hyporeactivitydendritic cellstolerancematurationlong-term graft survival
Abstract
The maturation of antigen-presenting dendritic cells (DCs) serves as an important determinant for the regulation of immunity, and overall immune response. We hypothesized that a reduced immune response to donor alloantigens and improved allograft survival could be induced by pre-treating recipients with bone-marrow-derived donor-strain fixed immature DCs (FIDCs). Donor-strain-derived mature and immature DCs were fixed before grafting to ensure that they possessed a stable immunogenic phenotype. The fixed mature DCs effectively induced allogeneic T-cell proliferation in recipients, whereas FIDCs were unable to elicit an allogeneic T-cell response. T cells that had previously been exposed to FIDCs maintained naive phenotypes and were unable to extensively divide after injection into lethally irradiated donor-strain mice. The pre-treatment of recipients with donor-strain FIDCs markedly prolonged the survival of islet as well as skin allografts. However, T-cell hyporesponsiveness induced by FIDC injection was abrogated by the depletion of CD4+ CD25+ T cells. Consequently, FIDC-induced T-cell hyporesponsiveness could reflect anergy rather than specific deletion. Our findings suggest that FIDCs of donor strain could be used to induce long-term graft survival.
ISSN
0019-2805
Language
English
URI
https://hdl.handle.net/10371/78685
DOI
https://doi.org/10.1111/j.1365-2567.2009.03158.x
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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