S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 23 No.2 (1982)
시상하부-뇌하수체-부신계 조절에 대한 Monoamine 신경전달물질의 역할에 관한 연구(1) -Monoamines과 Corticosteroid의 일주기 변동에 관하여
Roles of Monoamines Neurotransmitters in Regulation of Hypothalamo-Pituitary-Adrenal Axis
- 이정수; 서유헌; 박찬웅
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.23 No.2, pp. 181-187
- It has been known for many years that several
putative neurotransmitters have been involved both
in the control of circadian rhythmicity and stress
induced stimulation of hypothalamo-pituitary-adrenal
Most has been learned about the roles of dopamine
(DA), norepinephrineCNE), and serotonin(5-HT)
on secretion of this pituitary hormone. Despite
extensive work on the influence of hypothalamic
neurotransmitters on secretion of this hormone in the
last 15 years, it is stiII uncertain which transmitters
and which pathways play important regulatory roles,
but some evidence indicates that a variety of differ'
ent transmitters would be involved.
The purposes of the present study are to determine
that the circadian rhythmicity of the levels of monoaminesCNE,
DA, 5- HT) in whole brain and that
of plasma corticosterone levels are present and further more to assess correlations between the
circadian rhythmicity of the levels of these monoamines
and that of plasma corticosterone levels in
rats. Rats maintained on a 12-hr photoperiod 0600
to 1800 (CST) followed by 12 hr of darkness.
The results are summarized as follow:
1. The mean levels of the plasma corticosterone
(expressed as I'g/100ml plasma) showed a peak
level at 6:00 PM(38.815) and lowest level at
10:00 AM(24.826). The difference between highest
level and lowest level is statistically significant
(PZ. The mean levels of 5-HT In whole brain (expressed
as I'g/g of brain) showed two peaks at
12:00 AM and at 4:00 AM(0.466, 0.468 respectively),
and lowest level at 8:00 PM(O. 370). The
difference between the highest level and lowest
level is statistically significant (P3. The brain DA levels showed two peaks at 6:00
PM and at 10:00 AM(0.590, 0.577 respectively),
reaching the lowest level at 6:00 AM(0.530).
The difference between the highest level and
lowest level is not statistically significant.
4. The brain NE levels revealed multiple peaks
those are not significantly different.
5. No definite correlation between the circadian rhythmicity
of brain DA and NE levIes and that of
plasma corticosterone levels was observed. but
there may be reverse relationship between 5-HT
system and plasma corticosterone.