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Retinoid X receptor a acts as alpha negative regulator in Nurr1-induced dopaminergic differentiation in rat neural precursor cells

Cited 2 time in Web of Science Cited 2 time in Scopus
Authors
Yoon, Eun-Hye; Lee, Kuem Ju; Kim, Yong-Seok; Chang, Mi-Sook; Park, Chang-Hwan; Lee, Sang-Hun
Issue Date
2010-12-29
Publisher
Wolters Kluwer Health
Lippincott Williams & Wilkins
Citation
Neuroreport Vol.21 No.18, pp.1162-1166
Keywords
dopaminergic differentiationretinoid X receptor alphaNurr1rat embryonic neural precursor cells
Abstract
To investigate the role of retinoid X receptor alpha (RXR alpha)-Nurr1 heterodimers in tyrosine hydroxylase (TH) expression, we observed retrovirus-induced RXR alpha-Nurr1 heterodimer interactions with, and transactivation of, the TH promoter region in cultured rat embryonic neural precursor cells. Interestingly, forced expression of RXR alpha with Nurr1 remarkably reduced Nurr1 activity in TH + dopaminergic neuron generation and significantly down-regulated TH promoter activity. These regulatory activities were altered in both Nurr1(dim-) and RXR alpha(dim-) that disrupted dimeric binding, verifying that the Nurr1-RXR alpha heterodimer represses TH promoter activity. Therefore, a plausible explanation for the inhibitory role of RXR alpha in Nurr1-induced TH expression is that RXR alpha differentially affects an inhibitory element of the TH promoter. NeuroReport 21: 1162-1166 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
ISSN
0959-4965
1473-558X(Online)
Language
English
URI
https://hdl.handle.net/10371/80361
DOI
https://doi.org/10.1097/WNR.0b013e328340ccf9

https://doi.org/10.1097/WNR.0b013e328340ccf9
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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