Browse

Osteoconductive and degradable electrospun nonwoven poly(epsilon-caprolactone)/CaO-SiO2 gel composite fabric

Cited 16 time in Web of Science Cited 16 time in Scopus
Authors
Seol, Yang-Jo; Kim, Kyoung-Hwa; Kim, In Ae; Rhee, Sang-Hoon
Issue Date
2010-08
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A; Vol.94A, No.2, pp.649-659
Keywords
poly(epsilon-caprolactone)CaO-SiO2 gelcompositeosteoconductivitydegradabilityelectrospinning
Abstract
A nonwoven ceramic/polymer composite fabric composed of randomly mixed bioactive and fast degradable CaO-SiO2 gel fibers and biodegradable poly(epsilon-caprolactone) (PCL) fibers is prepared with a simultaneous electrospinning method for potential use as bone grafting materials. A 17% PCL solution is prepared using 1,1,3,3-hexafluoro-2-propanol as the solvent, whereas the CaO-SiO2 gel solution is prepared via a condensation reaction following the hydrolysis of tetraethyl orthosilicate. PCL and CaO-SiO2 gel solutions are spun simultaneously with two separate nozzles. As controls, pure PCL and CaO-SiO2 gel nonwoven fabrics are also made by the same methods. The three nonwoven fabrics were exposed to simulated body fluid for 1 week and resulted in the deposition of a layer of apatite crystals on the surfaces of both the CaO-SiO2 gel and PCL/CaO-SiO2 gel composite fabrics, but not on the PCL fabric. A tensile strength test showed that the fracture behavior of the CaO-SiO2 gel fabric was brittle, that of the PCL fabric was ductile-tough, and that of the PCL/CaO-SiO2 gel composite fabric was intermediate between that of the CaO-SiO2 gel and PCL fabrics. Our in vivo tests showed that the CaO-SiO2 gel and PCL/CaO-SiO2 gel composite fabrics had good osteoconductivity and fast degradation rates in calvarial defects of New Zealand white rabbits within 4 weeks, in contrast to the pure PCL fabric. Together, these results suggest that the composite fabric composed of PCL and CaO-SiO2 gel fibers must have a great potential for use in applications such as bone grafting because of its good osteoconductivity and adequate mechanical properties. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 94A: 649-659, 2010
ISSN
1549-3296
Language
English
URI
http://hdl.handle.net/10371/80410
DOI
https://doi.org/10.1002/jbm.a.32738
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse