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Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans

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dc.contributor.authorJang, J.Y.-
dc.contributor.authorPark, E.K.-
dc.contributor.authorRyoo, H.M.-
dc.contributor.authorShin, H.I.-
dc.contributor.authorJang, J.S.-
dc.contributor.authorChoi, J.Y.-
dc.contributor.authorKwon, T.G.-
dc.contributor.authorPark, H.S.-
dc.contributor.authorKim, T.H.-
dc.date.accessioned2013-01-21T07:28:57Z-
dc.date.available2013-01-21T07:28:57Z-
dc.date.issued2010-
dc.identifier.citationJournal of Dental Research; Vol.89, No.11, pp.1203-1207ko_KR
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10371/80881-
dc.description.abstractPrevious linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19??97.57, P < 0.05), whereas the 7987 AA genotype showed a protective effect for mandibular prognathism (OR = 0.16, 95% Cl = 0.05??.47, P < 0.05). Genotyping results showed that the Matrilin-1 polymorphism haplotype TGC (ht4; 158T, 7987G, and 8572C alleles) had a pronounced risk effect for mandibular prognathism compared with controls (OR = 5.16, 95% Cl = 2.03??3.93, P < 0.01). The results suggest that polymorphisms in Matrilin-1 could be used as a marker for genetic susceptibility to mandibular prognathism. ⓒ 2010 International & American Associations for Dental Research.ko_KR
dc.language.isoenko_KR
dc.publisherSAGEko_KR
dc.subjectmandibular prognathismko_KR
dc.subjectMatrilin-1ko_KR
dc.subjectSNPko_KR
dc.subjectpolymorphismko_KR
dc.titlePolymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreansko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor장지영-
dc.contributor.AlternativeAuthor박의균-
dc.contributor.AlternativeAuthor류현모-
dc.contributor.AlternativeAuthor신홍인-
dc.contributor.AlternativeAuthor최제용-
dc.contributor.AlternativeAuthor권대근-
dc.contributor.AlternativeAuthor박효상-
dc.identifier.doi10.1177/0022034510375962-
dc.citation.journaltitleJournal of Dental Research-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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