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Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, J.Y. | - |
dc.contributor.author | Park, E.K. | - |
dc.contributor.author | Ryoo, H.M. | - |
dc.contributor.author | Shin, H.I. | - |
dc.contributor.author | Jang, J.S. | - |
dc.contributor.author | Choi, J.Y. | - |
dc.contributor.author | Kwon, T.G. | - |
dc.contributor.author | Park, H.S. | - |
dc.contributor.author | Kim, T.H. | - |
dc.date.accessioned | 2013-01-21T07:28:57Z | - |
dc.date.available | 2013-01-21T07:28:57Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Journal of Dental Research; Vol.89, No.11, pp.1203-1207 | ko_KR |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80881 | - |
dc.description.abstract | Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19??97.57, P < 0.05), whereas the 7987 AA genotype showed a protective effect for mandibular prognathism (OR = 0.16, 95% Cl = 0.05??.47, P < 0.05). Genotyping results showed that the Matrilin-1 polymorphism haplotype TGC (ht4; 158T, 7987G, and 8572C alleles) had a pronounced risk effect for mandibular prognathism compared with controls (OR = 5.16, 95% Cl = 2.03??3.93, P < 0.01). The results suggest that polymorphisms in Matrilin-1 could be used as a marker for genetic susceptibility to mandibular prognathism. ⓒ 2010 International & American Associations for Dental Research. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SAGE | ko_KR |
dc.subject | mandibular prognathism | ko_KR |
dc.subject | Matrilin-1 | ko_KR |
dc.subject | SNP | ko_KR |
dc.subject | polymorphism | ko_KR |
dc.title | Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 장지영 | - |
dc.contributor.AlternativeAuthor | 박의균 | - |
dc.contributor.AlternativeAuthor | 류현모 | - |
dc.contributor.AlternativeAuthor | 신홍인 | - |
dc.contributor.AlternativeAuthor | 최제용 | - |
dc.contributor.AlternativeAuthor | 권대근 | - |
dc.contributor.AlternativeAuthor | 박효상 | - |
dc.identifier.doi | 10.1177/0022034510375962 | - |
dc.citation.journaltitle | Journal of Dental Research | - |
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