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Effects of epidural TNF-alpha inhibitor injection: analysis of the pathological changes in a rat model of chronic compression of the dorsal root ganglion

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Authors
Kim, Na Ra; Lee, Joon Woo; Jun, Su Ryoung; Lee, In Joon; Lim, So Dug; Yeom, Jin Sup; Koo, Kyung-Hoi; Jin, Wook; Kang, Heung Sik
Issue Date
2012-05
Publisher
SPRINGER
Citation
SKELETAL RADIOLOGY Vol.41 No.5, pp. 539-545
Keywords
의약학SciaticaSpineEpidural injectionTumor necrosis factor-alphaInhibitorNerve injury
Abstract
To evaluate the efficacy of a single direct epidural injection of tumor necrosis factor (TNF)-alpha inhibitor to reduce the pathological changes in nerve fiber injuries in a rat model of chronic compression of the dorsal root ganglion (CCD).A surgical procedure for CCD was performed in 17 adult male F-344 rats. The effects of the epidural TNF-alpha inhibitors on CCD-induced pathological changes were investigated. Three groups of rats (n = 17) were used: (1) CCD + saline (n = 4), (2) CCD + triamcinolone (n = 5), and (3) CCD + TNF-alpha inhibitors (n = 8). Their dorsal root ganglia and nerve roots were removed on postoperative day 14. The intraneural edema, demyelination, and Wallerian degeneration of all 17 rats were scored pathologically.The pathology scores of the rats in the TNF-alpha inhibitor treatment group (1.38 +/- 0.74) indicated a mild degree of intraneural edema compared to the saline treatment group (2.25 +/- 0.50, p = 0.041). In addition, rats in the TNF-alpha inhibitor treatment group (2.13 +/- 0.35) had a mild degree of demyelination compared to the saline treatment group (2.75 +/- 0.50, p = 0.038) and the triamcinolone treatment group (2.80 +/- 0.45, p = 0.019). The differences in the pathology scores for Wallerian degeneration were not statistically significant in all three study groups (p = 0.658).The epidural injection of a TNF-alpha inhibitor was more effective than a placebo and comparable to triamcinolone in reducing pathological nerve injury progression.
Objectives To evaluate the efficacy of a single direct epidural
injection of tumor necrosis factor (TNF)-α inhibitor to reduce
the pathological changes in nerve fiber injuries in a rat model
of chronic compression of the dorsal root ganglion (CCD).
Materials and methods A surgical procedure for CCD was
performed in 17 adult male F-344 rats. The effects of the
epidural TNF-α inhibitors on CCD-induced pathological changes were investigated. Three groups of rats (n=17)
were used: (1) CCD+saline (n=4), (2) CCD+triamcinolone
(n=5), and (3) CCD+TNF-α inhibitors (n=8). Their dorsal
root ganglia and nerve roots were removed on postoperative
day 14. The intraneural edema, demyelination, andWallerian
degeneration of all 17 rats were scored pathologically.
Results The pathology scores of the rats in the TNF-α
inhibitor treatment group (1.38±0.74) indicated a mild
degree of intraneural edema compared to the saline treatment
group (2.25±0.50, p=0.041). In addition, rats in the TNF-α
inhibitor treatment group (2.13±0.35) had a mild degree of
demyelination compared to the saline treatment group
(2.75±0.50, p=0.038) and the triamcinolone treatment
group (2.80±0.45, p=0.019). The differences in the
pathology scores for Wallerian degeneration were not
statistically significant in all three study groups (p=0.658).
Conclusion The epidural injection of a TNF-α inhibitor was
more effective than a placebo and comparable to triamcinolone
in reducing pathological nerve injury progression.
ISSN
0364-2348
Language
English
URI
https://hdl.handle.net/10371/81114
DOI
https://doi.org/10.1007/s00256-011-1222-3
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College of Medicine/School of Medicine (의과대학/대학원)Orthopedic Surgery (정형외과학전공)Journal Papers (저널논문_정형외과학전공)
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