S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Biomedical Sciences (대학원 의과학과) Journal Papers (저널논문_의과학과)
Urinary N-acetyl-ß-D Glucosaminidase as a Surrogate Marker for Renal Function in Autosomal Dominant Polycystic Kidney Disease : 1 year Prospective Cohort Study
- Park, Hayne Cho; Hwang, Jin Ho; Kang, Ah-Young; Ro, Han; Kim, Myung-Gyu; An, Jung Nam; Park, Ji In; Kim, Seung Hyup; Yang, Jaeseok; Oh, Yun Kyu; Oh, Kook-Hwan; Noh, Jung Woo; Cheong, Hae Il; Hwang, Young-Hwan; Ahn, Curie
- Issue Date
- BIOMED CENTRAL
- BMC NEPHROLOGY Vol.13 No.1, pp. 93-102
- Background: Renal failure is one of the most serious complications associated with autosomal dominant polycystic
kidney disease (ADPKD). To date, early markers have failed to predict renal function deterioration at the early stages.
This 1-year prospective study evaluated N-acetyl-β-D-glucosaminidase (NAG) as a new surrogate marker for renal
function in ADPKD.
Methods: A total of 270 patients were enrolled in the study, and we measured urinary NAG, β2-microglobulin,
neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) prospectively for 1 year to
compare their predictive values for renal function.
Results: Baseline urinary NAG/Cr was negatively correlated with estimated glomerular filtration rate (GFR) (r2 = 0.153,
P < 0.001) and positively correlated with total kidney volume (TKV) (r2 = 0.113, P < 0.001). Among other biomarkers,
urinary NAG/Cr better discriminated patients with decreased renal function from those with conserved renal
function, showing the largest area under the curve (AUC 0.794). Immunohistochemical study revealed strong
staining along the cyst-lining epithelial cells as well as the nearby compressed tubular epithelial cells. However,
both single and repeated measurements of urinary NAG/Cr failed to predict renal function decline in 1 year.
Conclusions: Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients.