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Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells

Cited 43 time in Web of Science Cited 53 time in Scopus
Authors
Ko, Seong Gyu; Kim, Hwang-Phill; Jin, Dong-Hoon; Bae, Hyun-Su; Kim, Sung Hoon; Park, Chong-Hyeong; Lee, Jung Weon
Issue Date
2005-03
Publisher
ELSEVIER IRELAND LTD
Citation
CANCER LETTERS Vol.220 No.1, pp. 11-19
Keywords
복합학Gastric cancerSaussurea lappaApoptosisp53Growth arrestATM/ATR
Abstract
The molecular effects of Saussurea lappa extracts, a traditional medicine in Eastern Asia, on the fate of gastric carcinoma have not been understood. In this study, its cytostatic effects were examined using gastric AGS cancer cells. Its treatment resulted in apoptosis and G2-arrest in a dose- and time-dependent manner. The effects were attributed to the regulation of cyclins and pro-apoptotic molecules and suppression of anti-apoptotic molecules. Therefore, these results suggest that extracts of S. lappa root may be a candidate to deal with gastric cancers either by traditional herbal therapy or by combinational therapy with conventional chemotherapy. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
ISSN
0304-3835
Language
English
URI
https://hdl.handle.net/10371/82047
DOI
https://doi.org/10.1016/j.canlet.2004.06.026
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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