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The extracellular loop 2 of TM4SF5 inhibits integrin alpha 2 on hepatocytes under collagen type I environment

Cited 22 time in Web of Science Cited 22 time in Scopus
Authors
Lee, Sin-Ae; Kim, Young Mee; Kwak, Tae Kyoung; Kim, Hyeon Jung; Kim, Semi; Ko, Wonil; Kim, Sung-Hoon; Park, Ki Hun; Kim, Hyun Jeong; Cho, Moonjae; Lee, Jung Weon
Issue Date
2009-11
Publisher
Oxford University Press
Citation
CARCINOGENESIS Vol.30 No.11, pp. 1872-1879
Keywords
복합학
Abstract
Four-transmembrane L6 family member 5 (TM4SF5) and its homolog L6, a tumor antigen, form a four-transmembrane L6 family. TM4SF5 expression causes uncontrolled cell proliferation and angiogenesis. Although other genuine transmembrane 4 superfamily (TM4SF) members co-operate with integrins for cell migration, roles of TM4SF5 in the cellular spreading and migration are unknown. Using hepatocarcinoma cell clones that ectopically express TM4SF5, we found that cross talks via an extracellular interaction between TM4SF5 and integrin alpha 2 in collagen type I environment inhibited integrin alpha 2 functions such as spreading on and migration toward collagen I, which were recovered by suppression of TM4SF5 or structural disturbance of its second extracellular loop using a peptide or mutagenesis. Altogether, the observations suggest that TM4SF5 in hepatocytes negatively regulates integrin alpha 2 function via an interaction between the extracellular loop 2 of TM4SF5 and integrin alpha 2 during cell spreading on and migration through collagen I environment.
ISSN
0143-3334
Language
English
URI
https://hdl.handle.net/10371/82057
DOI
https://doi.org/10.1093/carcin/bgp234
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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