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Modulation of signaling between TM4SF5 and integrins in tumor microenvironment

Cited 21 time in Web of Science Cited 22 time in Scopus
Authors
Lee, Sin-Ae; Park, Ki Hun; Lee, Jung Weon
Issue Date
2011-01
Publisher
FRONTIERS IN BIOSCIENCE INC
Citation
FRONTIERS IN BIOSCIENCE-LANDMARK Vol.16 No.5, pp. 1752-1758
Keywords
복합학CancerEpithelial-Mesenchymal TransitionHepatocarcinomaIntegrinMicroenvironmentTM4SF5Review
Abstract
TM4SF5 is a transmembrane glycoprotein of the
transmembrane 4 L six family, a branch of the tetraspanin
family and highly expressed in many types of cancers.
TM4SF5 induces epithelial-mesenchymal transition (EMT)
by morphological changes resulting from inactivation of
RhoA mediated by stabilized cytosolic p27kip1. TM4SF5-
mediated EMT can lead to loss of contact inhibition and
enhanced migration/invasion, presumably depending on
cross-talks between TM4SF5 and integrins. An anti-
TM4SF5 agent appears to target the second extracellular
domain of TM4SF5, which is important for cross-talk with
integrins, leading to a blockade of TM4SF5-mediated
multilayer growth and migration/invasion. In addition,
TM4SF5 engages in cross-talk with integrin alpha5 to
induce and secrete VEGF, which in turn causes activation
of angiogenesis in endothelial cells. Therefore, TM4SF5
plays a central regulatory role in a wide variety of
physiological processes through cross-talk with integrins.
This review presents current knowledge from in vitro and
in vivo observations of the roles of TM4SF5-integrin
cooperation in hepatocellular carcinogenesis and discusses
important areas for future investigation.
ISSN
1093-9946
Language
English
URI
https://hdl.handle.net/10371/82066
DOI
https://doi.org/10.2741/3818
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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