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Enhancing Nanoparticle-Based Visible Detection by Controlling the Extent of Aggregation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Seokwon | - |
dc.contributor.author | Koo, Ok Kyung | - |
dc.contributor.author | You, Young Sang | - |
dc.contributor.author | Lee, Yeong Eun | - |
dc.contributor.author | Kim, Min-Sik | - |
dc.contributor.author | Chang, Pahn-Shick | - |
dc.contributor.author | Kang, Dong Hyun | - |
dc.contributor.author | Yu, Jae-Hyuk | - |
dc.contributor.author | Choi, Young Jin | - |
dc.contributor.author | Gunasekaran, Sundaram | - |
dc.creator | 최영진 | - |
dc.date.accessioned | 2013-04-18T07:09:55Z | - |
dc.date.available | 2013-04-18T07:09:55Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | SCIENTIFIC REPORTS Vol.2 No.456, pp. 1-6 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82137 | - |
dc.description.abstract | Visible indication based on the aggregation of colloidal nanoparticles (NPs) is highly advantageous for rapid on-site detection of biological entities, which even untrained persons can perform without specialized instrumentation. However, since the extent of aggregation should exceed a certain minimum threshold to produce visible change, further applications of this conventional method have been hampered by insufficient sensitivity or certain limiting characteristics of the target. Here we report a signal amplification strategy to enhance visible detection by introducing switchable linkers (SLs), which are designed to lose their function to bridge NPs in the presence of target and control the extent of aggregation. By precisely designing the system, considering the quantitative relationship between the functionalized NPs and SLs, highly sensitive and quantitative visible detection is possible. We confirmed the ultrahigh sensitivity of this method by detecting the presence of 20 femto-M of streptavidin and fewer than 100 CFU/mL of Escherichia coli. | en |
dc.description.uri | This work is licensed under a Creative Commons
Attribution-NonCommercial-ShareAlike 3.0 Unported License | - |
dc.language.iso | en | en |
dc.publisher | NATURE PUBLISHING GROUP | en |
dc.subject | 자연과학 | en |
dc.subject | Sensors | - |
dc.subject | Modelling and Theory | - |
dc.subject | Optical Materials and Devices | - |
dc.subject | Nanobiotechnology | - |
dc.title | Enhancing Nanoparticle-Based Visible Detection by Controlling the Extent of Aggregation | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석원 | - |
dc.contributor.AlternativeAuthor | 구옥경 | - |
dc.contributor.AlternativeAuthor | 유영상 | - |
dc.contributor.AlternativeAuthor | 이영은 | - |
dc.contributor.AlternativeAuthor | 김민식 | - |
dc.contributor.AlternativeAuthor | 장판식 | - |
dc.contributor.AlternativeAuthor | 강동현 | - |
dc.contributor.AlternativeAuthor | 유재혁 | - |
dc.contributor.AlternativeAuthor | 최영진 | - |
dc.identifier.doi | 10.1038/srep00456 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000047059/3 | - |
dc.description.srnd | SEQ:3 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000047059 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A077087 | - |
dc.description.srnd | DEPT_CD:5321 | - |
dc.description.srnd | FILENAME:12-06-srep00456.pdf | - |
dc.description.srnd | DEPT_NM:농생명공학부 | - |
dc.description.srnd | EMAIL:choiyj@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:N | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000047059/3 | - |
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