포도구균 및 녹농균의 실험적 혼합감염증에 미치는 접종시간 간격의 영향

Abstract

Of late it was roported that the cases of mixed bactorial infections, due to Staph. aureus, Es. coli, the proteus, the pseudomonas and others, are increasing. The exact mechanilms, however, of mixed infections are not well cIearified. It was thought that the time lapse in bacterial introduction into body tissue might produce signifcant influences on the course of infections. To investigate this possibliity, Staph. au reus and Ps, aeruginosa were cultercd aerobically in Brain-Heart Infusion Broth at 37°C. and inoculated into ear vein of rabbits together with, or with time lapse of 1 hour or 24 +011 i:: it oI "6" uJ s1;<] Z1 'V;.:il .k% Ps. aeruginosa i:: 3°.1 7iJ 7J}7'j ~7} 6j-.:il a: .f. ~ 7'\l71~;>;1 t:!l;\1].£.- ~7Jol 'ict~ it4- °1':ct4· 2. !£."-Tit 1:J * 1 "'17,} + Ps. aeruginasa 1:J *.;c The heart blood and the urire were taken asoptically and the viable units number of both species in the specimons were followed. The resilts of observation might be summerized as follows. 1. When the stophylococci and the pseudomonas were inoculated simultaneously, ; From the blood stream the viable units of both species disappecred raiidly, The viable units of staphylococcus in the unine initiated marked increase after 2-3 days of infection and continued through 7 days. The viable units of pseudomonas in the urine increased slowly until the 3rd day and then showed no noticiable increase or decrease through the 7th day. 2. When the psedomonas were inoculated 1 hour after the inoculation of staphylococci'; The population curve patterns of both bacterial species in both blood and unine were almost same with those of the simultaneous inocuation group. 3. When the pseudomones were inoculated 24 hours after the inoculation of staphylococci'; The staphylococci disappeared rapidly from the blood, but showed small and transient increase after the inoculation of psoudomonas, The staphylococci in the urire increased rapidly, without intial delay, until the 3rd day, no noticiable change in numbor until the 5th day, and then decreased. The psoudomonas in the blood disappeared rapidly from the blood and could not be recovered after 1 day through 7 days. The pseudomonas in the uri no showed small but persistont number until the 4th day and some increase after that.