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Mimicking the human smell sensing mechanism with an artificial nose platform

Cited 72 time in Web of Science Cited 81 time in Scopus
Authors
Lee, Sang Hun; Kwon, Oh Seok; Song, Hyun Seok; Park, Seon Joo; Sung, Jong Hwan; Jang, Jyongsik; Park, Tai Hyun
Issue Date
2012-02
Publisher
Elsevier Ltd.
Citation
Biomaterials Vol.33 No.6, pp. 1722-1729
Keywords
복합학Nanobioelectronic noseHuman olfactory receptorConducting polymer nanotubeAntagonism
Abstract
Sensing smell is a highly complex biological process, and characterizing and mimicking the interaction between the olfactory receptor (OR) protein and its ligands is extremely challenging. Herein, we report a highly sensitive and selective human nose-like nanobioelectronic nose (nbe-nose), which responds to gaseous odorants sensitively and selectively, has a signal specificity pattern similar to that in the cellular signal transduction pathway, and maintains an antagonistic behavior similar to the human nose. The human olfaction mechanism was mimicked by using carboxylated polypyrrole nanotubes (CPNTs) functionalized with human OR protein. The nbe-nose was able to detect gaseous odorants at a concentration as low as 0.02 parts-per-trillion (ppt), which was comparable to a highly trained, human expert's nose. The nbe-nose can be used scientifically for smell mechanism studies. It can be also applied to various fields that rely on smell monitoring for industrial and public purposes. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN
0142-9612
Language
English
URI
https://hdl.handle.net/10371/83139
DOI
https://doi.org/10.1016/j.biomaterials.2011.11.044
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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