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Ultrasensitive and Selective Recognition of Peptide Hormone Using Close-Packed Arrays of hPTHR-Conjugated Polymer Nanoparticles
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Oh Seok | - |
dc.contributor.author | Ahn, Sae Ryun | - |
dc.contributor.author | Park, Seon Joo | - |
dc.contributor.author | Song, Hyun Seok | - |
dc.contributor.author | Lee, Sang Hun | - |
dc.contributor.author | Lee, Jun Seop | - |
dc.contributor.author | Hong, Jin-Yong | - |
dc.contributor.author | Lee, James S. | - |
dc.contributor.author | You, Sun Ah | - |
dc.contributor.author | Yoon, Hyeonseok | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.contributor.author | Jang, Jyongsik | - |
dc.creator | 박태현 | - |
dc.date.accessioned | 2013-07-31T00:16:42Z | - |
dc.date.available | 2013-07-31T00:16:42Z | - |
dc.date.created | 2018-07-09 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | ACS Nano, Vol.6 No.6, pp.5549-5558 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://hdl.handle.net/10371/83141 | - |
dc.description.abstract | Recognition of diverse hormones in the human body is a highly significant challenge because numerous diseases can be affected by hormonal imbalances. However, the methodologies reported to date for detecting hormones have exhibited limited performance. Therefore, development of innovative methods is still a major concern in hormone-sensing applications. In this study, we report an immobilization-based approach to facilitate formation of close-packed arrays of carboxylated polypyrrole nanoparticles (CPPyNPs) and their integration with human parathyroid hormone receptor (hPTHR), which is a B-class family of G-protein-coupled receptors (GPCRs). Our devices enabled use of an electrically controllable liquid-ion-gated field-effect transistor by using the surrounding phosphate-buffered saline solution (pH 7.4) as electrolyte solution. Field-induced signals from the peptide hormone sensors were observed and provided highly sensitive and selective recognition of target molecules at unprecedentedly low concentrations (ca. 48 fM). This hormone sensor also showed long-term stability and excellent selectivity in fetal bovine serum. Importantly, the hormone receptor attached on the surface of CPPyNPs enabled GPCR functional studies; synergistic effects corresponding to increased hPTH peptide length were monitored. These results demonstrate that close-packed CPPyNP arrays are a promising approach for high-performance biosensing devices. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | American Chemical Society | - |
dc.title | Ultrasensitive and Selective Recognition of Peptide Hormone Using Close-Packed Arrays of hPTHR-Conjugated Polymer Nanoparticles | - |
dc.type | Article | - |
dc.author.alternative | 권오석 | - |
dc.author.alternative | 안세련 | - |
dc.author.alternative | 박선주 | - |
dc.author.alternative | 송현석 | - |
dc.author.alternative | 이상헌 | - |
dc.author.alternative | 이준섭 | - |
dc.author.alternative | 홍진용 | - |
dc.author.alternative | 유선아 | - |
dc.author.alternative | 윤현석 | - |
dc.author.alternative | 박태현 | - |
dc.author.alternative | 장정식 | - |
dc.identifier.doi | 10.1021/nn301482x | - |
dc.citation.journaltitle | ACS Nano | - |
dc.identifier.wosid | 000305661300110 | - |
dc.identifier.scopusid | 2-s2.0-84862850309 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000002410/13 | - |
dc.description.srnd | SEQ:13 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000002410 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A002014 | - |
dc.description.srnd | DEPT_CD:458 | - |
dc.description.srnd | CITE_RATE:11.421 | - |
dc.description.srnd | FILENAME:(2012.6) Ultrasensitive and selective recognition of peptide hormone using.pdf | - |
dc.description.srnd | DEPT_NM:화학생물공학부 | - |
dc.description.srnd | EMAIL:thpark@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:N | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 5558 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 5549 | - |
dc.citation.volume | 6 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Tai Hyun | - |
dc.contributor.affiliatedAuthor | Jang, Jyongsik | - |
dc.identifier.srnd | 2012-01/102/0000002410/13 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SURFACE-PLASMON RESONANCE | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORS | - |
dc.subject.keywordPlus | HUMAN OLFACTORY RECEPTOR | - |
dc.subject.keywordPlus | CONDUCTING-POLYMER | - |
dc.subject.keywordPlus | PARATHYROID-HORMONE | - |
dc.subject.keywordPlus | POLYPYRROLE NANOPARTICLES | - |
dc.subject.keywordPlus | INORGANIC NANOPARTICLES | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | POTENTIAL APPLICATIONS | - |
dc.subject.keywordPlus | ENZYME-IMMUNOASSAY | - |
dc.subject.keywordAuthor | hormone receptor | - |
dc.subject.keywordAuthor | field-effect transistor | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | hormone sensor | - |
dc.subject.keywordAuthor | conducting polymer | - |
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