Publications
Detailed Information
Rule-based in vitro molecular classification and visualization
Cited 1 time in
Web of Science
Cited 2 time in Scopus
- Authors
- Issue Date
- 2013-03
- Publisher
- KOREAN BIOCHIP SOCIETY-KBCS
- Citation
- BIOCHIP JOURNAL, Vol.7 No.1, pp.29-37
- Abstract
- Molecular computing using programmable nucleic acids has been attracting attention for use in autonomous sensing systems and information processing systems by interacting with a biological environment. Here, we introduce a rule-based in vitro molecular classification system that can classify disease patterns using several microRNA (miRNA) markers via the assembly of programmed DNA strands. The classification rules were derived by analyzing large-scale miRNA expression data obtained from a public database, and the identified rules were converted into DNA sequences. Classification was performed via the detection of miRNA markers in the rules. The classification results were reported as a binary output pattern according to their hybridization to the rule sequences, which can be conveniently visualized using gold nanoparticle aggregation. Our results demonstrate the utility of in vitro molecular classification by illustrating one of the ways in which molecular computing can be used in future biological and medical applications.
- ISSN
- 1976-0280
- Language
- English
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.