Publications
Detailed Information
Chemical modification of chitosan as a gene carrier in vitro and in vivo
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae-Hee | - |
dc.contributor.author | Jiang, Hu-Lin | - |
dc.contributor.author | Jere, Dhananjay | - |
dc.contributor.author | Park, In-Kyu | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Nah, Jae-Woon | - |
dc.contributor.author | Choi, Yun-Jale | - |
dc.contributor.author | Akaike, Toshihiro | - |
dc.contributor.author | Cho, Chong-Su | - |
dc.date.accessioned | 2009-09-01 | - |
dc.date.available | 2009-09-01 | - |
dc.date.created | 2018-04-11 | - |
dc.date.issued | 2007-07 | - |
dc.identifier.citation | Progress in Polymer Science, Vol.32 No.7, pp.726-753 | - |
dc.identifier.issn | 0079-6700 | - |
dc.identifier.other | 31070 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8337 | - |
dc.description.abstract | Currently, the success of gene therapy is mainly limited due to the lack of effective vector systems. Although viral vectors are highly efficient in transfecting cells, undesirable complications limit their therapeutic applications. Chitosan has been investigated as a non-viral vector offering several advantages, such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, the low transfection efficiency and low cell specificity of chitosan as a DNA carrier need to be overcome before undertaking clinical trials. The objective of this review is to summarize the use of chitosan and chitosan derivatives in gene therapy, and particularly the role of several factors for the enhancement of transfection efficiency and cell specificity in vitro, such as the degree of deacetylation and molecular weight of chitosan, pH, serum, charge ratio of chitosan to DNA and cell type on transfection efficiency, chemical modification. The administration of the chitosan derivative formulations in vivo is also included, and, the role of chitosan as a carrier of controlled release of DNA and small interfering RNA is described. (c) 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Elsevier BV | - |
dc.title | Chemical modification of chitosan as a gene carrier in vitro and in vivo | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1016/j.progpolymsci.2007.05.001 | - |
dc.citation.journaltitle | Progress in Polymer Science | - |
dc.identifier.wosid | 000248435200003 | - |
dc.identifier.scopusid | 2-s2.0-34250901807 | - |
dc.citation.endpage | 753 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 726 | - |
dc.citation.volume | 32 | - |
dc.identifier.sci | 000248435200003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.contributor.affiliatedAuthor | Choi, Yun-Jale | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | RECEPTOR-MEDIATED ENDOCYTOSIS | - |
dc.subject.keywordPlus | SYNCYTIAL VIRUS-INFECTION | - |
dc.subject.keywordPlus | WATER-SOLUBLE CHITOSAN | - |
dc.subject.keywordPlus | ACID-MODIFIED CHITOSAN | - |
dc.subject.keywordPlus | N-ACETYLATED CHITOSAN | - |
dc.subject.keywordPlus | TARGETING DNA CARRIER | - |
dc.subject.keywordPlus | POLY-L-LYSINE | - |
dc.subject.keywordPlus | TRANSFECTION EFFICIENCY | - |
dc.subject.keywordPlus | DELIVERY-SYSTEM | - |
dc.subject.keywordAuthor | chitosan | - |
dc.subject.keywordAuthor | gene delivery | - |
dc.subject.keywordAuthor | cell specificity | - |
dc.subject.keywordAuthor | transfection efficiency | - |
dc.subject.keywordAuthor | chemical modification | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.