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Multiplex targeting, tracking, and imaging of apoptosis by fluorescent surface enhanced raman spectroscopic dots
DC Field | Value | Language |
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dc.contributor.author | Yu, Kyeong Nam | - |
dc.contributor.author | Lee, Sang-Myung | - |
dc.contributor.author | Han, Ji Yun | - |
dc.contributor.author | Park, Hyunmi | - |
dc.contributor.author | Woo, Min-Ah | - |
dc.contributor.author | Noh, Mi Suk | - |
dc.contributor.author | Hwang, Soon-Kyung | - |
dc.contributor.author | Kwon, Jung-Taek | - |
dc.contributor.author | Jin, Hua | - |
dc.contributor.author | Kim, Yong-Kweon | - |
dc.contributor.author | Hergenrother, Paul J. | - |
dc.contributor.author | Jeong, Dae Hong | - |
dc.contributor.author | Lee, Yoon-Sik | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2009-09-01 | - |
dc.date.available | 2009-09-01 | - |
dc.date.created | 2020-12-16 | - |
dc.date.issued | 2007-07 | - |
dc.identifier.citation | Bioconjugate Chemistry, Vol.18 No.4, pp.1155-1162 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.other | 119216 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8338 | - |
dc.description.abstract | We have developed multifunctional fluorescent surface enhanced Raman spectroscopic tagging material (F-SERS dots) composed of silver nanoparticle-embedded silica spheres with fluorescent organic dye and specific Raman labels for multiplex targeting, tracking, and imaging of cellular/molecular events in the living organism. In this study, F-SERS dots fabricated with specific target antibodies (BAX and BAD) were employed for the detection of apoptosis. The F-SERS dots did not show any particular toxicity in several cell lines. The F-SERS dots could monitor the apoptosis effectively and simultaneously through fluorescent images as well as Raman signals in both cells and tissues with high selectivity. Our results clearly demonstrate that F-SERS dots can be easily applicable to multiplex analysis of diverse cellular/molecular events important for maintaining cellular homeostasis. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | American Chemical Society | - |
dc.title | Multiplex targeting, tracking, and imaging of apoptosis by fluorescent surface enhanced raman spectroscopic dots | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1021/bc070011i | - |
dc.citation.journaltitle | Bioconjugate Chemistry | - |
dc.identifier.wosid | 000248085700018 | - |
dc.identifier.scopusid | 2-s2.0-34547140197 | - |
dc.citation.endpage | 1162 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1155 | - |
dc.citation.volume | 18 | - |
dc.identifier.sci | 000248085700018 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Kweon | - |
dc.contributor.affiliatedAuthor | Jeong, Dae Hong | - |
dc.contributor.affiliatedAuthor | Lee, Yoon-Sik | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SILICA SPHERES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | SCATTERING | - |
dc.subject.keywordPlus | PHOSPHATIDYLSERINE | - |
dc.subject.keywordPlus | NANOBIOTECHNOLOGY | - |
dc.subject.keywordPlus | REDISTRIBUTION | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | TAGS | - |
dc.subject.keywordPlus | SIZE | - |
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