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Histopathological features of bisphosphonate-associated osteonecrosis: findings in patients treated with partial mandibulectomies

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dc.contributor.authorCho, Young-Ah-
dc.contributor.authorYoon, Hye-Jung-
dc.contributor.authorLee, Jae-Il-
dc.contributor.authorHong, Sam-Pyo-
dc.contributor.authorHong, Seong-Doo-
dc.creator홍성두-
dc.date.accessioned2013-10-07T04:29:58Z-
dc.date.available2013-10-07T04:29:58Z-
dc.date.issued2012-12-
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Vol.114 No.6, pp. 785-791-
dc.identifier.issn2212-4403-
dc.identifier.urihttps://hdl.handle.net/10371/83536-
dc.description.abstractThe present study investigated the histopathologic and radiographic features of stage 3 bisphosphonate-associated osteonecrosis of the jaw (BAONJ) in patients who were treated with partial mandibulectomies. Bisphosphonates had been orally administered to 10 patients with osteoporosis and intravenously administered to 1 patient with metastatic carcinoma. On radiographic images, massive osteolysis and periosteal bone formations were conspicuous, and a thin mandibular cortical width was observed in 5 of 10 osteoporosis patients despite the previous use of bisphosphonate. Microscopically, the mandibulectomy specimens of the patients could be divided into 4 distinct layers. Although there were few differences in overall histologic features between BAONJ and chronic suppurative osteomyelitis, a notable number of osteoclasts were found detached from the bony trabeculae in BAONJ.en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.subject의약학en
dc.titleHistopathological features of bisphosphonate-associated osteonecrosis: findings in patients treated with partial mandibulectomiesen
dc.typeArticle-
dc.author.alternative조영아-
dc.author.alternative윤혜정-
dc.author.alternative이재일-
dc.author.alternative홍삼표-
dc.author.alternative홍성두-
dc.identifier.doi10.1016/j.oooo.2012.08.457-
dc.citation.journaltitleOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000004825/1-
dc.description.srndSEQ:1-
dc.description.srndPERF_CD:SNU2012-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000004825-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A075646-
dc.description.srndDEPT_CD:861-
dc.description.srndCITE_RATE:1.457-
dc.description.srndFILENAME:첨부된 내역이 없습니다.-
dc.description.srndDEPT_NM:치의학과-
dc.description.srndEMAIL:hongsd@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2012-01/102/0000004825/1-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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