Browse

Histopathological features of bisphosphonate-associated osteonecrosis: findings in patients treated with partial mandibulectomies

Cited 16 time in Web of Science Cited 16 time in Scopus
Issue Date
2012-12
Publisher
Elsevier Inc.
Citation
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Vol.114 No.6, pp. 785-791
Keywords
의약학
Abstract
The present study investigated the histopathologic and radiographic features of stage 3 bisphosphonate-associated osteonecrosis of the jaw (BAONJ) in patients who were treated with partial mandibulectomies. Bisphosphonates had been orally administered to 10 patients with osteoporosis and intravenously administered to 1 patient with metastatic carcinoma. On radiographic images, massive osteolysis and periosteal bone formations were conspicuous, and a thin mandibular cortical width was observed in 5 of 10 osteoporosis patients despite the previous use of bisphosphonate. Microscopically, the mandibulectomy specimens of the patients could be divided into 4 distinct layers. Although there were few differences in overall histologic features between BAONJ and chronic suppurative osteomyelitis, a notable number of osteoclasts were found detached from the bony trabeculae in BAONJ.
ISSN
2212-4403
Language
English
URI
https://hdl.handle.net/10371/83536
DOI
https://doi.org/10.1016/j.oooo.2012.08.457
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse