S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Histopathological features of bisphosphonate-associated osteonecrosis: findings in patients treated with partial mandibulectomies
- Issue Date
- Elsevier Inc.
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Vol.114 No.6, pp. 785-791
- The present study investigated the histopathologic and radiographic features of stage 3 bisphosphonate-associated osteonecrosis of the jaw (BAONJ) in patients who were treated with partial mandibulectomies. Bisphosphonates had been orally administered to 10 patients with osteoporosis and intravenously administered to 1 patient with metastatic carcinoma. On radiographic images, massive osteolysis and periosteal bone formations were conspicuous, and a thin mandibular cortical width was observed in 5 of 10 osteoporosis patients despite the previous use of bisphosphonate. Microscopically, the mandibulectomy specimens of the patients could be divided into 4 distinct layers. Although there were few differences in overall histologic features between BAONJ and chronic suppurative osteomyelitis, a notable number of osteoclasts were found detached from the bony trabeculae in BAONJ.
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