인삼의 중추신경계에 대한 작용

Abstract

The effect of Panax Ginseng saponin on central nervous system was reported by many authors. But there was no consistent opinion on central action of Ginseng. We studied the effects of Panax Ginseng saponin fraction on central nervous system through general behavior observation. open-field exploratory behavior and conditioned avoidance behavior. The results are as follow: 1) The general behavior of rat in home cage was not influenced by 2.5mg/kg of Ginseng saponin fraction. but 10mg/kg of Ginseng suppressed the general activity of rat. 2) Open-field exploratory behavior of rat was greatly increased by injection of 2.5mg/kg and 5.0 mg/Kg of Ginseng saponin fraction compared with control group. 3) ChlorpromazineCl. 25mg/g) suppressed the conditioned avoidance behavior of rat. On the other hand. Ginseng saponin fraction stimulated conditioned avoidance behavior of rat. 4) These results suggest that Panax Ginseng saponin fraction has the protective adaptogenic action.