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Neural Prosthesis in the Wake of Nanotechnology : Controlled Growth of Neurons Using Surface Nanostructures

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Authors
Lee, Jae Kyoo; Baac, Hyoungwon; Song, Sang Ho; Jang, Eun Je; Lee, Sin Doo; Park, Dong Eun; Kim, Sung June
Issue Date
2006-11
Publisher
Springer Verlag
Citation
Acta Neurochir Suppl 99: 141-144
Keywords
Photoresponsive polymersurface structureneural cell guidegrowth controlneural prosthesis
Abstract
Neural prosthesis has been successfully applied to patients with motional
or sensory disabilities for clinical purpose. To enhance the performance
of the neural prosthetic device, the electrodes for the biosignal
recording or electrical stimulation should be located in closer proximity
to target neurons than they are now. Instead of revising the prior implanting
surgery to improve the electrical contact of neurons, we propose a
technique that can bring the neurons closer to the electrode sites. A new
method is investigated that can control the direction of neural cell
growth using surface nanostructures. We successfully guide the neurons
to the position of the microelectrodes by providing a surface topographical
cue presented by the surface nanostructure on a photoresponsive
polymer material. Because the surface structure formed by laser holography
is reversible and repeatable, the geometrical positioning of the
neurons to microelectrodes can be adjusted by applying laser treatment
during the surgery for the purpose of improving the performance of
neural prosthetic device.
ISSN
0065-1419
Language
English
URI
https://hdl.handle.net/10371/8848
DOI
https://doi.org/10.1007/978-3-211-35205-2_27
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Journal Papers (저널논문_전기·정보공학부)
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