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Effects of Insertion Conditions on Tissue Strain and Vascular Damage during Neuroprosthetic Device Insertion

Cited 206 time in Web of Science Cited 223 time in Scopus
Authors
Bjornsson, C. S.; Oh, Seung Jae; Al-Kofahi, Y. A.; Lim, Y. J.; Smith, K. L.; Turner, J. N.; De, S.; Roysam, B.; Shain, W.; Kim, Sung June
Issue Date
2006-09
Publisher
Institute of Physics
Citation
J. Neural. Eng. 3 196-207
Abstract
Long-term integration of neuroprosthetic devices is challenged by reactive responses that
compromise the brain–device interface. The contribution of physical insertion parameters to
immediate damage is not well described. We have developed an ex vivo preparation to capture
real-time images of tissue deformation during device insertion using thick tissue slices from
rat brains prepared with fluorescently labeled vasculature. Qualitative and quantitative
assessments of damage were made for insertions using devices with different tip shapes
inserted at different speeds. Direct damage to the vasculature included severing, rupturing and
dragging, and was often observed several hundred micrometers from the insertion site. Slower
insertions generally resulted in more vascular damage. Cortical surface features greatly
affected insertion success; insertions attempted through pial blood vessels resulted in severe
tissue compression. Automated image analysis techniques were developed to quantify tissue
deformation and calculate mean effective strain. Quantitative measures demonstrated that,
within the range of experimental conditions studied, faster insertion of sharp devices resulted
in lower mean effective strain. Variability within each insertion condition indicates that
multiple biological factors may influence insertion success. Multiple biological factors may
contribute to tissue distortion, thus a wide variability was observed among insertions made
under the same conditions.
ISSN
1741-2560 (print)
1741-2552 (online)
Language
English
URI
http://hdl.handle.net/10371/8856
DOI
https://doi.org/10.1088/1741-2560/3/3/002
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Journal Papers (저널논문_전기·정보공학부)
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