S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Electrical and Computer Engineering (전기·정보공학부) Journal Papers (저널논문_전기·정보공학부)
Submicron-scale topographical control of cell growth using holographic surface relief grating
- Baac, Hyoungwon; Lee, Jeong-Hyun; Seo, Jong-Mo; Park, Tai Hyun; Chung, Hum; Lee, Sin-Doo; Kim, Sung June
- Issue Date
- Mater. Sci. Eng., C 24 (2004) 209
- Topographical control; Holography; Cell attachment; Cell orientation; Photo-responsive polymer; Surface relief grating
- The cell orientation and attachment were controlled by a submicron-scale topographical cue. For achieving the submicron undulation of
surface topography, the laser holography on a photo-responsive azobenzene copolymer layer has been employed to produce surface relief
grating (SRG) which has a regular sinusoidal shape. Cultured human astrocytes (HA) were preferentially attached onto the SRG surface and
highly elongated along the SRG direction. This topographical control scheme would be very efficient to control the cell growth for cellular
engineering applications and to understand the interactions of the cells with a submicron-scale topographical surface.
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