S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Electrical and Computer Engineering (전기·정보공학부) Journal Papers (저널논문_전기·정보공학부)
Biocompatibility of Polyimide Microelectrode Array for Retinal Stimulation
- Seo, Jong-Mo; Kim, Sung June; Chung, Hum; Kim, Eui Tae; Yu, Hyeong Gon; Yu, Young Suk
- Issue Date
- Mater. Sci. Eng., C 24 (2004) 185
- Biocompatibility; Cell culture; Implant material; Polyimide microelectrode; Retina; Visual prosthesis
- Artificial retina is aimed for the stimulation of remained retinal neurons in the patient with degenerated photoreceptors. Microelectrode
arrays have been developed for this as a part of stimulator. To minimize the damage during ophthalmic surgery and to get better contact to
retina, flexible polyimide, which can be fabricated based on semiconductor manufacturing, was selected as the substrate material. In vitro
biocompatibility of polyimide microelectrode array (MEA) was tested by co-culture with human retinal pigment epithelial cells (RPE). In
vivo biocompatibility was tested in the rabbit eyes. The polyimide MEA showed good affinity to human RPE and did no harmful effect. It
also showed very good stability and safety in rabbit eyes by 12 weeks.
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