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Highly selective and sensitive detection of neurotransmitters using receptor-modified single-walled carbon nanotube sensors

Cited 19 time in Web of Science Cited 24 time in Scopus
Authors
Kim, Byeongju; Song, Hyun Seok; Jin, Hye Jun; Park, Eun Jin; Lee, Sang Hun; Lee, Byung Yang; Park, Tai Hyun; Hong, Seunghun
Issue Date
2013-06-21
Publisher
IOP Publishing Ltd
Citation
Nanotechnology Vol.24 No.28, pp. 285-501
Keywords
복합학
Description
Online supplementary data available from stacks.iop.org/Nano/24/285501/mmedia
Abstract
We present receptor-modified carbon nanotube sensors for the highly selective and sensitive detection of acetylcholine (ACh), one kind of neurotransmitter. Here, we successfully expressed the M1 muscarinic acetylcholine receptor (M1 mAChR), a family of G protein-coupled receptors (GPCRs), in E. coli and coated single-walled carbon nanotube (swCNT)-field effect transistors (FETs) with lipid membrane including the receptor, enabling highly selective and sensitive ACh detection. Using this sensor, we could detect ACh at 100 pM concentration. Moreover, we showed that this sensor could selectively detect ACh among other neurotransmitters. This is the first demonstration of the real-time detection of ACh using specific binding between ACh and M1 mAChR, and it may lead to breakthroughs for various applications such as disease diagnosis and drug screening.
ISSN
0957-4484
Language
English
URI
https://hdl.handle.net/10371/90920
DOI
https://doi.org/10.1088/0957-4484/24/28/285501
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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