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A study on the prognostic value of clinical and surgical features of dermatofibrosarcoma protuberans in Korean patients

Cited 13 time in Web of Science Cited 12 time in Scopus
Authors
Kim, M.; Huh, C. H.; Cho, K. H.; Cho, S.
Issue Date
2012-08
Publisher
European Academy of Dermatology and Venereology
Blackwell Publishing
Citation
Journal of the European Academy of Dermatology and Venereology Vol.26 No.8, pp. 964-971
Keywords
복합학
Abstract
BACKGROUND : Dermatofibrosarcoma protuberans (DFSP) is a rare spindle cell tumour with locally aggressive characteristics. Only few studies on the epidemiology of DFSP in Asians have been reported.
OBJECTIVES : The purpose of the study was to evaluate the epidemiological and clinical characteristics of DFSP in Korean patients and determine the prognostic factors that affect disease-free survival.
METHODS : We conducted a retrospective review of patients diagnosed with primary or recurrent DFSP between 2000 and 2009 at three Seoul National University Hospitals. Patient, tumour and treatment factors were analysed for local recurrence-free survival.
RESULTS : We analysed data for 65 patients, of whom 36 (55.4%) were female. The mean age at disease onset was 34.4 years with 50% aged between 20 and 40 years. Involved sites were most often on the trunk (66.1%). Among the 65 patients, 60 patients underwent wide excision; seven patients (10.8%) experienced local recurrence during 3.6 years of follow-up. The recurrence-free survival was significantly related to the microscopic resection margins (P = 0.005), clinical presentation (P = 0.002) and frequency of recurrence (P = 0.014) in the univariate analysis. There were three cases with metastasis, two of whom died because of progression of the disease despite continuous chemotherapy with imatinib mesylate.
CONCLUSIONS : We report the epidemiologic and clinical characteristics of DFSP in Korea. Patients with recurrent disease at presentation and frequent recurrence have a high risk of recurrence and metastasis, and therefore close observation is needed in these patients.
ISSN
0926-9959 (print)
1468-3083 (online)
Language
English
URI
https://hdl.handle.net/10371/91053
DOI
https://doi.org/10.1111/j.1468-3083.2011.04190.x
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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