Browse

Emerging Roles of Orphan Nuclear Receptors in Cancer

Cited 26 time in Web of Science Cited 25 time in Scopus
Authors
Baek, Sung Hee; Kim, Keun Il
Issue Date
2013-11
Publisher
ANNUAL REVIEWS
Citation
Annual Review of Physiology, Vol.2014 No.76, pp. 177-195
Keywords
자연과학ERRsRORsNur77LRH-1p53β-catenin
Abstract
A growing body of evidence suggests that a subset of orphan nuclear receptors are amplified and prognostic for some human cancers. However, the specific roles of these orphan nuclear receptors in tumor progression and their utility as drug targets are not fully understood. In this review, we summarize recent progress in elucidating the direct and indirect involvement of orphan nuclear receptors in cancer as well as their therapeutic potential in a variety of human cancers. Furthermore, we contrast the role of orphan nuclear receptors in cancer with the known roles of estrogen receptor and androgen receptor in hormone-dependent cancers.
ISSN
0066-4278
Language
English
URI
https://hdl.handle.net/10371/91659
DOI
https://doi.org/10.1146/annurev-physiol-030212-183758
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse