S-Space College of Natural Sciences (자연과학대학) Dept. of Biological Sciences (생명과학부) Journal Papers (저널논문_생명과학부)
Emerging Roles of Orphan Nuclear Receptors in Cancer
- Baek, Sung Hee; Kim, Keun Il
- Issue Date
- ANNUAL REVIEWS
- Annual Review of Physiology, Vol.2014 No.76, pp. 177-195
- A growing body of evidence suggests that a subset of orphan nuclear receptors are ampliﬁed and prognostic for some human cancers. However, the speciﬁc roles of these orphan nuclear receptors in tumor progression and their utility as drug targets are not fully understood. In this review, we summarize recent progress in elucidating the direct and indirect involvement of orphan nuclear receptors in cancer as well as their therapeutic potential in a variety of human cancers. Furthermore, we contrast the role of orphan nuclear receptors in cancer with the known roles of estrogen receptor and androgen receptor in hormone-dependent cancers.
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