S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Neurology (신경과학교실) Journal Papers (저널논문_신경과학교실)
Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials
- Jung, Ki-Young; Cho, Jae-Wook; Joo, Eun Yeon; Kim, Sun Hwa; Choi, Kyung Mook; Chin, Juhee; Park, Kun-Woo; Hong, Seung Bong
- Issue Date
- Clinical Neurophysiology, Vol.121 No.9, pp. 1494-1501
- 공학; Topiramate; Cognitive function; Event-related potential (ERP); Standardised low-resolution; electromagnetic tomography (sLORETA); Source localisation
- Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy.Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA).Results: Neuropsychological tests (n = 18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n = 13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions.Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects.Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.
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